"Glycosaminoglycan Binding and Non-endocytic Membrane Translocation of Cell-permeable Octaarginine Monitored by Real Time In-cell NMR Spectroscopy"
Y. Takechi-Haraya, K. Aki, Y. Tohyama, Y. Harano, T. Kawakami, H. Saito, and E. Okamura, Pharmaceuticals, 10, 42 (2017).
"Kinetics of the competitive reactions of isomerization and peptide bond cleavage at L-α- and D-β-aspartyl residues in an αA-crystallin fragment"
K. Aki and E. Okamura, J. Pept. Sci., 23, 28-37 (2017).
"D-β-aspartyl residue exhibiting uncommon high resistance to spontaneous peptide bond cleavage"
K. Aki and E. Okamura, Sci. Rep., 6, 21594 (2016).
総説
" Kinetics of Membrane Binding and Mobility of Drugs by Multinuclear Dynamic NMR in Situ "
E. Okamura, Journal of the Society of Japanese Women Scientists, 16, 7-14 (2016).
著書
"NMR of Drug Delivery Coupled with Lipid Membrane Dynamics"
E.Okamura, in Encyclopedia of Biocolloid and Biointerface Science, Ed. by H. Ohshima, Volume 1, Chapter 30, pp. 391-402, John Wiley & Sons, Inc., 2016.
日本膜学会 膜誌論文賞(2016)
Y. Takechi, Y. Shintani, D. Kimoto, and E. Okamura, "Regulation of Phospholipid Protrusion in the Cell Sized Vesicle by Hydrophobic Bisphenol A", Membrane, 40, 38-45 (2015).
2015年
原著論文
"Staggered side-chain conformers of aspartyl residues prerequisite to transformation from L-α- to D-β-aspartate 58 in human-lens αA-crystallin fragment"
K. Aki and E. Okamura, Biophys. Chem., 196, 10-15 (2015).
"Regulation of Phospholipid Protrusion in the Cell Sized Vesicle by Hydrophobic Bisphenol A"
Y. Takechi, Y. Shintani, D. Kimoto, and E. Okamura, Membrane, 40, 38-45 (2015). 日本膜学会 「膜誌論文賞」受賞論文
招待講演
"Mobility, location, and kinetics of membrane binding and delivery of drugs by solution-state 19F and 1H NMR",
E. Okamura, 6th Asian Conference on Colloid and Interface Science, November 24-27, 2015, Sasebo, Nagasaki, Japan.
"Uptake of Sevoflurane Limited by the Presence of Cholesterol in the Lipid Bilayer Membrane: A Multinuclear Nuclear Magnetic Resonance Study"
E. Okamura, Y. Takechi, and K. Aki, J. Oleo Sci., 63, 1149-1157 (2014).
"Slow Tumbling but Large Protrusion of Phospholipids in the Cell Sized Giant Vesicle"
Y. Takechi, H. Saito, and E. Okamura, Chem. Phys. Lett., 570, 136-140 (2013).
"Lateral Diffusion of Lipids Separated from Rotational and Translational Diffusion of a Fluid Large Unilamellar Vesicle"
N. Yoshii, T. Emoto, and E. Okamura, Colloid Surf. B-Biointerfaces, 106, 22-27 (2013).
"Physicochemical Mechanism for the Lipid Membrane Binding of Polyarginine: the Favorable Enthalpy Change with Structural Transition from Random Coil to Alpha-Helix"
Y. Takechi, C. Mizuguchi, M. Tanaka, T. Kawakami, S. Aimoto, E. Okamura, and H. Saito, Chem. Lett., 41, 1374-1376 (2012).
"Binding of Hydrophobic Fluorinated Bisphenol A to Large Unilamellar Vesicles of Egg Phosphatidylcholine"
N. Yoshii, and E. Okamura, J. Phys. Chem. B, 115, 11074-11080 (2011).
"Kinetics of Binding and Diffusivity of Leucine-Enkephalin in Large Unilamellar Vesicle by Pulsed-Field-Gradient 1H NMR in Situ"
N. Yoshii, T. Emoto, and E. Okamura, Biophysics, 7, 105-111 (2011).
"Kinetics of Membrane Binding and Dissociation of 5-Fluorouracil by Pulsed-Field-Gradient 19F NMR "
N. Yoshii and E.Okamura, Chem. Phys. Lett., 474, 357-361 (2009).
"Drug Binding and Mobility in Membranes by High-Resolution Solution NMR"
E. Okamura, The 47th Annual Meeting of the Biophysical Society of Japan, 2009年10月30日~11月1日 (Tokushima)
"Drug Binding and Mobility Relating to the Thermal Fluctuation in Fluid Lipid Membranes"
E.Okamura and N. Yoshii, J. Chem. Phys., 129, 215102-1~8 (2008).
"Cholesterol Location and Orientation in Aqueous Suspension of Large Unilamellar Vesicles of Phospholipid Revealed by Intermolecular Nuclear Overhauser Effect"
C.Giordani, C.Wakai, K.Yoshida, E.Okamura, N.Matubayasi, and M.Nakahara, J. Phys. Chem. B, 112, 2622-2628 (2008).
招待講演
"Drug Binding and Mobility in Model Cell Membranes in Situ: A Pulsed-Field-Gradient NMR Approach"
E. Okamura, Special Seminar, University of Pittsburgh, Molecular Biophysics and Structural Biology, June 19, 2008, Pittsburgh, USA