姫路獨協大学薬学部 生化学研究室

姫路獨協大学 薬学部 医療薬学科

 生化学研究室

Division of Biochemistry

R0018944-5.jpg 

| HOME | 研究業績 |  

Adobe FlashPlayer 9 or above is required for proper exhibition of this page. Enter Adobe homepage from HERE for Downloading the free software.

原著論文
 


Tsujioka T, Yokoi A, Itano Y, Takahashi K, Ouchida M, Okamoto S, Kondo T, Suemori S, Tohyama Y, *Tohyama K: Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells. Sci Rep. 5:16709, doi:10.1038/srep16709, 2015. Abstract

 

Harahap NI, Nurputra DK, Rochmah MA, Shima A, Morisada N, Takarada T, Takeuchi A, Tohyama Y Yanagisawa S, Nishio H: Salbutamol inhibits ubiquitin-mediated survival motor neuron protein degradation in spinal muscular atrophy cells. Biochem Biophys Rep. 4: 351–356, doi:10.1016/j.bbrep.2015.10.012, 2015.

 

Kuroda Y, *Kato-Kogoe N, Tasaki E, Yuasa-Sunagawa M, Yamanegi K, Nakasyo K, Nakase I, Futaki S, Tohyama Y, Hirose M:Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells. Eur J Pharmacol.765: 24-33, 2015. Abstract

 

Yamamoto T, Sato H, Lai PS, Nurputra DK, Harahap NI, Morikawa S, Nishimura N, Kurashige T, Ohshita T, Nakajima H, Yamada H, Nishida Y, Toda S, Takanashi JI, Takeuchi A, Tohyama Y,  Kubo Y, Saito K, Takeshima Y, Matsuo M, *Nishio H: Intragenic mutations in SMN1 may contribute more significantly to clinical severity than SMN2 copy numbers in some spinal muscular atrophy (SMA) patients. Brain Dev. 36(10): 914-20, 2014. Abstract

 

Kawakami T, He J, Morita H, Yokoyama K, Kaji H, Tanaka C, Suemori S, Tohyama K, Tohyama Y: Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells PLoS One 9(1):e84704. 2014 Abstract

 

Nurputra DK, Lai PS, Harahap NI, Morikawa S, Yamamoto T, Nishimura N, Kubo Y, Takeuchi A, Saito T, Takeshima Y, Tohyama Y, Tay SK, Low PS, Saito K, Nishio H: Spinal Muscular Atrophy: From Gene Discovery to Clinical Trials. Ann Hum Genet. 77(5):435-463. 2013 Abstract

 

Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F: Tubulin Polymerization Promoting Protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem. 288 (24):17313-35 2013 Abstract

 

Kuroda Y, Kato-Kogoe N, Tasaki E, Murata E, Ueda K, Abe M, Miyamoto K, Nakase I, Futaki S, Tohyama Y, Hirose M: Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells. Eur J Pharmacol. 698(1-3):87-94 2013 Abstract

 

Tsujioka T, Yokoi A, Kishimoto M, Kuyama A, Suemori S, Tohyama Y, Tohyama K: Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-deribed cell lines. Exp Hematol. 41(2):189-97 2013 Abstract

 

Tsujioka T, Matsuoka A, Tohyama Y, Tohyama K. Approach to New Therapeutics: Investigation by the Use of MDS-derived Cell Lines. Curr Pharm Des. 18(22):3204-14 2012 Review Abstract

 

Tanaka C, Kaji H, He J, Hazama R, Yokoyama K, Kinoshita E, Tsujioka T, Tohyama K, Yamamura H, Nishio H, Tohyama Y: Rab27b regulates c-kit expression by controling the secretion of stem cell factor. Biochem Biophys. Res Commun. 419(2): 368-73 (2012). Abstract

 

Yokoyama K, Kaji H, He J, Tanaka C, Hazama R, Kamigaki T, Ku Y, Tohyama K, Tohyama Y : Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes J Biol Chem. 286 (7):5375-82 (2011). Abstract

 

Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC: Protein kinase C delta-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases J Biol Chem. 285(53): 41896-910 (2010) Abstract

 

Matsuoka A, Tochigi A, Kishimoto M, Nakahara T, Kondo T, Tsujioka T, Tasaka T, Tohyama Y, Tohyama K: Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis. Leukemia. 4: 748-55 (2010) Abstract

 

Hazama R, Qu X, Yokoyama K, Tanaka C, Kinoshita E, He J, Takahashi S, Tohyama K, Yamamura H, Tohyama Y: ATP-induced osteoclast function; the formation of sealing-zone like structure and the secretion of lytic granules via microtubule-deacetylation under the control of Syk. Genes to Cells 14: 871-84. (2009)  Abstract

 

Tohyama Y, Yamamura H: Protein-Tyrosine Kinase, Syk: A Key Player in Phagocytic Cells. J Biochem. 145(3): 267-73. (2009) Review  Abstract

 

Kondo T, Okuno N, Naruse H, Kishimoto M, Tasaka T, Tsujioka T, Matsuoka A, Sugihara T, Tohyama Y, Tohyama K: Validation of the revised 2008 WHO diagnostic criteria in 75 suspected cases of myeloproliferative neoplasm. Leuk Lymphoma. 49(9): 1784-91. (2008) Abstract

 

Noda C, He J, Takano T, Tanaka C, Kondo T, Tohyama K, Yamamura H, Tohyama Y: Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells. Biochem Biophys Res Commun. 362:951-957. (2007) Abstract

 

Tohyama Y, Yamamura H. Complement-mediated phagocytosis - the role of Syk. IUBMB Life. 58(5): 304-308 (2006). Review Abstract

 

Shi Y, Tohyama Y, Kadono T, He J, Miah SMS, Hazama R, Tanaka C, Tohyama K, Yamamura H: Protein-tyrosine kinase, Syk is required for pathogen engulfment in complement-mediated phagocytosis. Blood. 107: 4554-4562, (2006)  Abstract

 

Kurihara R, Tohyama Y, Matsusaka S, Kinoshita E, Naruse H, Tsujioka T, Katsumata Y, Yamamura H: Effects of peripheral cannabinoid receptor ligands on motility and polarization neutrophil-like HL60 cells and human neutrophils. J Biol Chem. 281: 12908-12918, (2006)  “Paper of the Week  Abstract

 

Matsusaka, M., Tohyama, Y., He, J., Shi, Y., Hazama, R., Kadono, T., Kurihara, R., Tohyama, K., and Yamamura, H. Protein-tyrosine kinase, Syk is required for CXCL12-induced polarization of B cells. Biochem Biophys. Res Commun. 328(4): 1163-1169 (2005)

 

He, J., Tohyama, Y., Yamamoto, K., Kobayashi, M., Shi, Y., Takano, T., Noda, C., Tohyama, K., and Yamamura, H.  Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function. Genes to Cells 10: 23-35 (2005)

 

Tohyama, Y., Takano,T., and Yamamura,H. B cell response to oxidative stress. Curr Pharm Des. 10(8):835-839 (2004) Review

 

Miah, S.M.S., Sada, K., Tuazon, P. T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J.A. and Yamamura, H. Activation of Syk protein-tyrosine kinase in response to osmotic stress requires the interaction with p21-activated protein kinase Pak2/-PAK. Mol Cell Biol. 24(1):71-83 (2004)

 

Nishihara T, Miura Y, Tohyama Y, Mizutani C, Hishita T, Ichiyama S, Uchiyama T, Tohyama K. Effects of the tyrosine kinase inhibitor imatinib mesylate on a Bcr-Abl-positive cell line: suppression of autonomous cell growth but no effect on decreased adhesive property and morphological changes. Int J Hematol. 78(3):233-40 (2003).

 

Tohyama, Y., Katagiri, K., Pardi, R., Lu, C., Springer, T-A. and Kinashi, T. The critical cytoplasmic regions of the lphaL/eta2 integrin in Rap1-induced adhesion and migration. Mol Biol Cell 14(6): 2570-2582 (2003)

 

Mizutani, C., Tohyama, Y., Miura, Y., Hishita, T., Nishihara, T., Yamamura, H., Ichiyama, S., Uchiyama, T. and Tohyama, K. Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation. Biochem Biophys. Res Commun. 297(3): 664-671 (2002)

 

Miura, H., Mizutani, C., Nishihara, T., Hishita, H., Yanagi, S., Tohyama, Y., Ichiyama, S., Yamamura, H., Uchiyama, T. and Tohyama, K. Adhesion via CD43 induces Syk activation and cell proliferation in TF-1 cells. Biochem Biophys. Res Commun. 288(1):80-86 (2001)

 

Hishita, T., Tada-Oikawa, S., Tohyama, K., Miura, Y., Nishihara, T., Tohyama, Y., Yoshida, Y., Uchiyama, T. and Kawanishi, S. Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Cancer Res. 61(7):2878-84 (2001)

 

Asahi, M., Azuma, T., Ito, S., Ito, Y., Suto, H., Nagai, Y., Tsubokawa, M., Tohyama, Y., Maeda, S., Omata, M., Suzuki, T. and Sasakawa, C. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med. 191(4):593-602 (2000)

 

Miura, Y., Tohyama, Y., Hishita, T., Lala A., De Nardin E., Yoshida, Y., Yamamura, H., Uchiyama, T. and Tohyama, K. Pyk2 and Syk participate in functional activation of granulocytic HL-60 cells in a different manner. Blood. 96(5):1733-1739 (2000)

 

Tohyama Y, Tohyama K, Tsubokawa M, Asahi M, Yoshida Y and Yamamura H. Outside-in signaling of soluble and solid-phase fibrinogen through integrin IIb3 is different and co-operative with each other in a megakaryoblastic leukemia cell line, CMK. Blood. 92(4):1277-1286, (1998).

 

Tsubokawa M, Tohyama Y, Tohyama K, Asahi M, Inazu T, Nakamura H, Saito H and Yamamura H. Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193. Eur J Biochem. 249(3):792-796, 1997.

 

Tohyama K, Tohyama Y, Nakayama T, Ueda T, Nakamura T and Yoshida Y. A novel factor-dependent human myelodysplastic cell line, MDS92, contains haemopoietic cells of several lineages. Br J Haematol. 91(4):795-799, 1995.

 

Tohyama Y, Yanagi S, Sada K and Yamamura H. Translocation of p72syk to the cytoskeleton in thrombin-stimulated platelets. J Biol Chem. 269(52):32796-32799, 1994.

 

Yanagi S, Sada K, Tohyama Y, Tsubokawa M, Nagai K, Yonezawa K and Yamamura H. Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation. Eur J Biochem. 224(2):329-333, 1994.

 

和文

通山由美 山村博平 Sykの発見から臨床応用まで 炎症と免疫
 2012; 20(5月号):272-277 特集II 低分子抗炎症薬の進歩 において

 

通山由美  補体依存性ファゴサイトーシスの分子機構-チロシンキナーゼSykの新たな機能  生化学 2006;78:878-882 みにれびゅう