学部・大学院

教員紹介

谷口 泰造 [たにぐち たいぞう]

写真

薬学部医療薬学科:分子病態学研究室 教授

【連絡先】
部屋番号:Y506

https://sites.google.com/site/molecularpathophysiology/

専門分野

  • 内科学
  • 薬理学
  • 分子病態学

担当科目

  • 病態生理学 I
  • 病態生理学 II
  • 臨床医学各論
  • 診断学
  • 再生医学
  • 薬学応用演習 II
  • 薬学応用演習 III
  • 病態解析学実習
  • 症例検討統合演習(PBL)

メッセージ

6年間、共に切磋琢磨しよう。

学歴

神戸大学大学院医学系研究科 修了(1995)
神戸大学医学部 卒業(1988)

学位

博士(医学)

主な職歴

2009-
姫路獨協大学薬学部 教授
2011-
株式会社ファルマクリエ神戸 代表取締役
2007-2009
姫路獨協大学薬学部 客員教授
2002-2005
神戸大学バイオシグナル研究センター 講師
1995-2002
兵庫県立高齢者脳機能研究センター 研究部基礎研究科研究員 兼 内科医長
1989-1991
兵庫県立淡路病院内科 医員
1988-1989
神戸大学医学部 研修医

所属学会

日本薬理学会(評議員)
日本神経化学会(評議員)
日本内科学会

受賞歴

平成13年度 日本神経化学会奨励賞

著書・翻訳書

  • 「口から始める健康と美容」編著&分担執筆第7章 口腔粘膜と美容 p147 - p159
  • T. Taniguchi, S. Matsuyama, K. Minoura, H. Iso, M. Sasaki, K. Tomoo, T. Ishida, H. Mori, C. Tanaka: Learning Deficits in N279K Tau Transgenic Mice and an Assembly Model of Tau Protein. Molecular Neurobiology of Alzheimer Disease and Related Disorders, 01/2004: pages 183-194; , ISBN: 3-8055-7603-X, DOI:10.1159/000078538
  • Toshio Kawamata, Taizo Taniguchi, Hideyuki Mukai, Takeshi Hashimoto, Hiroshi Hasegawa, Niu San-Yu, Akira Terashima, Masamichi Nakai, Minoru Yasuda, Kiyoshi Maeda, Yoshitaka Ono, Koho Miyoshi, Chikako Tanaka: Possible role of tau phosphorylation on ER membrane in Alzheimer pathology. Neuroscientific Basis of Dementia, 01/2001: pages 121-128; , DOI:10.1007/978-3-0348-8225-5_14

論文・解説

  • Hideki Azuma, Jiawei Li, Ryota Youda, Toshio Suzuki, Kazuhide Miyamoto, Taizo Taniguchi, Takeshi Nagasaki: Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins. DOI:10.1016/j.jarmap.2016.01.002
  • Mariko Takenokuchi, Kazuhide Miyamoto, Katsuyasu Saigo, Taizo Taniguchi: Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML-RARA. Anticancer research 06/2015; 35(6):3307-16.
  • Tomohiro Umeda, Hiroshi Eguchi, Yuichi Kunori, Yoichi Matsumoto, Taizo Taniguchi, Hiroshi Mori, Takami Tomiyama: Passive immunotherapy of tauopathy targeting pSer413-tau: A pilot study in mice. 03/2015; 2(3)., DOI:10.1002/acn3.171
  • Lucia S Yoshida, Shunji Kohri, Shohko Tsunawaki, Tomohito Kakegawa, Taizo Taniguchi, Hiromi Takano-Ohmuro, Hirotada Fujii: Evaluation of radical scavenging properties of shikonin. Journal of Clinical Biochemistry and Nutrition 09/2014; 55(2):90-6., DOI:10.3164/jcbn.13-107
  • Koushirou Sogawa, Katsuhiko Minoura, Yasuko In, Toshimasa Ishida, Taizo Taniguchi, Koji Tomoo: CH-π interaction in VQIVYK sequence elucidated by NMR spectroscopy is essential for PHF formation of tau. Biopolymers 05/2014; 102(3)., DOI:10.1002/bip.22489
  • Jhoana Mendoza, Michiko Sekiya, Taizo Taniguchi, Koichi M Iijima, Rong Wang, Kanae Ando: Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro. Journal of Proteome Research 04/2013; 12(6)., DOI:10.1021/pr400008f
  • Takashi Kato, Hiroshi Funakoshi, Keiichi Kadoyama, Satsuki Noma, Masaaki Kanai, Wakana Ohya-Shimada, Shinya Mizuno, Nobutaka Doe, Taizo Taniguchi, Toshikazu Nakamura: Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in mice. Journal of Neuroscience Research 09/2012; 90(9):1743-55., DOI:10.1002/jnr.23065
  • Koushirou Sogawa, Ryouhei Okuda, Yasuko In, Toshimasa Ishida, Taizo Taniguchi, Katsuhiko Minoura, Koji Tomoo: C-H ... interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four-repeat tau. Journal of Biochemistry 06/2012; 152(3):221-9., DOI:10.1093/jb/mvs061
  • Shunmei Chiba, Erika Takada, Mamoru Tadokoro, Taizo Taniguchi, Keiichi Kadoyama, Mariko Takenokuchi, Seiya Kato, Noboru Suzuki: Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy. Neurobiology of aging 12/2011; 33(10):2491-505., DOI:10.1016/j.neurobiolaging.2011.11.002
  • Mieko Otani, Taizo Taniguchi, Akiko Sakai, Jouji Seta, Keiichi Kadoyama, Tooru Nakamura-Hirota, Shogo Matsuyama, Keiji Sano, Masaoki Takano: Phosphoproteome Profiling Using a Fluorescent Phosphosensor Dye in Two-Dimensional Polyacrylamide Gel Electrophoresis. Applied biochemistry and biotechnology 03/2011; 164(6):804-18., DOI:10.1007/s12010-011-9175-5
  • Takaaki Nishimoto, Keiichi Kadoyama, Taizo Taniguchi, Masaoki Takano, Mieko Otani, Tooru Nakamura-Hirota, Yabin Lu, Akira Matsumoto, Shogo Matsuyama: Synaptotagmin1 synthesis induced by synaptic plasticity in mouse hippocampus through activation of nicotinic acetylcholine receptors. Neuroscience Letters 02/2011; 489(1):25-9., DOI:10.1016/j.neulet.2010.11.059
  • Keiko Naruto, Katsuhiko Minoura, Ryouhei Okuda, Taizo Taniguchi, Yasuko In, Toshimasa Ishida, Koji Tomoo: Interplay between I308 and Y310 residues in the third repeat of microtubule-binding domain is essential for tau filament formation. FEBS letters 10/2010; 584(19):4233-6., DOI:10.1016/j.febslet.2010.09.012
  • Mitsunobu Doi, Toshimasa Ishida, Yoshio Katsuya, Masahiro Sasaki, Taizo Taniguchi, Hiroshi Hasegawa, Tsutomu Mimoto, Yoshiaki Kiso: ChemInform Abstract: KNI-272, a Highly Selective and Potent Peptidic HIV Protease Inhibitor. ChemInform 03/2010; 33(9)., DOI:10.1002/chin.200209193
  • Mariko Takenokuchi, Keiichi Kadoyama, Shunmei Chiba, Miho Sumida, Shogo Matsuyama, Katsuyasu Saigo, Taizo Taniguchi: SJLB mice develop tauopathy-induced parkinsonism. Neuroscience Letters 02/2010; 473(3):182-5., DOI:10.1016/j.neulet.2010.02.032
  • Masaoki Takano, Mieko Otani, Akiko Sakai, Keiichi Kadoyama, Shogo Matsuyama, Akira Matsumoto, Mariko Takenokuchi, Miho Sumida, Taizo Taniguchi: Use of a phosphosensor dye in proteomic analysis of human mutant tau transgenic mice. Neuroreport 11/2009; 20(18):1648-53., DOI:10.1097/WNR.0b013e328333b0e0
  • Chisato Nishiura, Kengo Takeuchi, Katsuhiko Minoura, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishida: Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein. Journal of Biochemistry 11/2009; 147(3):405-14., DOI:10.1093/jb/mvp181
  • Etsuko Sugino, Chisato Nishiura, Katsuhiko Minoura, Yasuko In, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishida: Three-/four-repeat-dependent aggregation profile of tau microtubule-binding domain clarified by dynamic light scattering analysis. Biochemical and Biophysical Research Communications 06/2009; 385(2):236-40., DOI:10.1016/j.bbrc.2009.05.047
  • Shogo Matsuyama, Taizo Taniguchi, Keiichi Kadoyama, Akira Matsumoto: Matsuyama S, Taniguchi T, Kadoyama K, Matsumoto A. Long-term potentiation-like facilitation through GABAA receptor blockade in the mouse dentate gyrus in vivo. Neuroreport 19: 1809-1813. Neuroreport 11/2008; 19(18):1809-13., DOI:10.1097/WNR.0b013e328319ab94
  • Masaki Hattori, Etsuko Sugino, Katsuhiko Minoura, Yasuko In, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishida: Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. Biochemical and Biophysical Research Communications 08/2008; 374(1):158-63., DOI:10.1016/j.bbrc.2008.07.001
  • Kayoko Okuyama, Chisato Nishiura, Fumie Mizushima, Katsuhiko Minoura, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishida: Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein. FEBS Journal 05/2008; 275(7):1529-39., DOI:10.1111/j.1742-4658.2008.06312.x
  • Masamichi Nakai, Kaori Hojo, Keiko Yagi, Naoaki Saito, Taizo Taniguchi, Akira Terashima, Toshio Kawamata, Takeshi Hashimoto, Kiyoshi Maeda, Michael Gschwendt, Hideyuki Yamamoto, Eishichi Miyamoto: Amyloid β Protein (25-35) Phosphorylates MARCKS Through Tyrosine Kinase-Activated Protein Kinase C Signaling Pathway in Microglia. Journal of Neurochemistry 03/2008; 72(3):1179-1186., DOI:10.1046/j.1471-4159.1999.0721179.x
  • Fumie Mizushima, Katsuhiko Minoura, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida: Marked Difference Between Self-aggregations of First and Fourth Repeat Peptides on Tau Microtubule-binding Domain in Acidic Solution. Journal of Biochemistry 08/2007; 142(1):49-54., DOI:10.1093/jb/mvm099
  • A Asano, T Yamada, Y Katsuya, T Taniguchi, M Sasaki, M Doi: Conformational restraints induced by modification of configuration of threonine and oxazoline residues in ascidiacyclamide analogues. European Journal of Allergy and Clinical Immunology 12/2006; 66 Suppl 1:90-8., DOI:10.1111/j.1747-0285.2006.00345.x
  • Fumie Mizushima, Katsuhiko Minoura, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida: Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain. Biochemical and Biophysical Research Communications 06/2006; 343(3):712-8., DOI:10.1016/j.bbrc.2006.02.185
  • Koji Tomoo, Yasunori Matsushita, Hiroyuki Fujisaki, Fumi Abiko, Xu Shen, Taizo Taniguchi, Hiroo Miyagawa, Kunihiro Kitamura, Kin-ichiro Miura, Toshimasa Ishida: Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. Biochimica et Biophysica Acta 01/2006; 1753(2):191-208., DOI:10.1016/j.bbapap.2005.07.023
  • Naoko Adachi, Miho Oyasu, Taizo Taniguchi, Yasuto Yamaguchi, Rika Takenaka, Yasuhito Shirai, Naoaki Saito: Immunocytochemical localization of a neuron-specific diacylglycerol kinase β and γ in the developing rat brain. Molecular Brain Research 11/2005; 139(2):288-99., DOI:10.1016/j.molbrainres.2005.06.007
  • M Doi, A Asano, H Yoshida, M Inouguchi, K Iwanaga, M Sasaki, Y Katsuya, T Taniguchi, D Yamamoto: Structure and property of self-assemble valinyl bolaform amides having different chirality. Chemical Biology & Drug Design 11/2005; 66(4):181-9., DOI:10.1111/j.1399-3011.2005.00286.x
  • Taizo Taniguchi, Nobutaka Doe, Shogo Matsuyama, Yoshihisa Kitamura, Hiroshi Mori, Naoaki Saito, Chikako Tanaka: Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation. FEBS Letters 11/2005; 579(25):5704-12., DOI:10.1016/j.febslet.2005.09.047
  • Koji Tomoo, Tian-Ming Yao, Katsuhiko Minoura, Shuko Hiraoka, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida: Possible role of each repeat structure of the microtubule-binding domain of the tau protein in in vitro aggregation. Journal of Biochemistry 11/2005; 138(4):413-23., DOI:10.1093/jb/mvi142
  • Mari Tokimasa, Katsuhiko Minoura, Shuko Hiraoka, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida: Importance of local structures of second and third repeat fragments of microtubule-binding domain for tau filament formation. FEBS Letters 08/2005; 579(17):3481-6., DOI:10.1016/j.febslet.2005.05.020
  • Katsuhiko Minoura, Fumie Mizushima, Mari Tokimasa, Shuko Hiraoka, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida: Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain. Biochemical and Biophysical Research Communications 03/2005; 327(4):1100-4., DOI:10.1016/j.bbrc.2004.12.129
  • Taizo Taniguchi, Miho Sumida, Shuko Hiraoka, Koji Tomoo, Tomoko Kakehi, Katsuhiko Minoura, Shigeru Sugiyama, Koji Inaka, Toshimasa Ishida, Naoaki Saito, Chikako Tanaka: Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation. FEBS Letters 03/2005; 579(6):1399-404., DOI:10.1016/j.febslet.2005.01.039
  • Masamitsu Kuriyama, Taizo Taniguchi, Yasuhito Shirai, Atsuo Sasaki, Akihiko Yoshimura, Naoaki Saito: Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochemical and Biophysical Research Communications 12/2004; 325(3):843-51., DOI:10.1016/j.bbrc.2004.10.102
  • Shuko Hiraoka, Tian-Ming Yao, Katsuhiko Minoura, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida: Conformational transition state is responsible for assembly of microtubule-binding domain of tau protein. Biochemical and Biophysical Research Communications 04/2004; 315(3):659-63., DOI:10.1016/j.bbrc.2004.01.107
  • Katsuhiko Minoura, Tian-Ming Yao, Koji Tomoo, Miho Sumida, Masahiro Sasaki, Taizo Taniguchi, Toshimasa Ishida: Different associational and conformational behaviors between the second and third repeat fragments in tau microtubule-binding domain. European Journal of Biochemistry 03/2004; 271(3):545-52., DOI:10.1046/j.1432-1033.2003.03956.x
  • Katsuhiko Minoura, Koji Tomoo, Toshimasa Ishida, Hiroshi Hasegawa, Masahiro Sasaki, Taizo Taniguchi: Solvent-Dependent Conformation of the Third Repeat Fragment in the Microtubule-Binding Domain of Tau Protein, Analyzed by 1H-NMR Spectroscopy and Molecular Modeling Calculation. Bulletin of the Chemical Society of Japan 08/2003; 76(8):1617-1624., DOI:10.1246/bcsj.76.1617
  • Tian-Ming Yao, Koji Tomoo, Toshimasa Ishida, Hiroshi Hasegawa, Masahiro Sasaki, Taizo Taniguchi: Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods. Journal of Biochemistry 08/2003; 134(1):91-9., DOI:10.1093/jb/mvg116
  • Koji Tomoo, Xu Shen, Koumei Okabe, Yoshiaki Nozoe, Shoichi Fukuhara, Shigenobu Morino, Masahiro Sasaki, Taizo Taniguchi, Hiroo Miyagawa, Kunihiro Kitamura, Kin-ichiro Miura, Toshimasa Ishida: Structural Features of Human Initiation Factor 4E, Studied by X-ray Crystal Analyses and Molecular Dynamics Simulations. Journal of Molecular Biology 05/2003; 328(2):365-83., DOI:10.1016/S0022-2836(03)00314-0
  • Takeshi Hashimoto, Toshio Kawamata, Naoaki Saito, Masahiro Sasaki, Masamichi Nakai, Sanyoung Niu, Taizo Taniguchi, Akira Terashima, Minoru Yasuda, Kiyoshi Maeda, Chikako Tanaka: Isoform‐Specific Redistribution of Calcineurin Aα and Aβ in the Hippocampal CA1 Region of Gerbils After Transient Ischemia. Journal of Neurochemistry 11/2002; 70(3):1289 - 1298., DOI:10.1046/j.1471-4159.1998.70031289.x
  • Akiko Asano, Takeshi Yamada, Atsushi Numata, Yoshio Katsuya, Masahiro Sasaki, Taizo Taniguchi, Mitsunobu Doi: A flat squared conformation of an ascidiacyclamide derivative caused by chiral modification of an oxazoline residue. Biochemical and Biophysical Research Communications 10/2002; 297(1):143-7., DOI:10.1016/S0006-291X(02)02088-0
  • K. Tomoo, X. Shen, K. Okabe, Y. Nozoe, S. Fukuhara, S. Morino, T. Ishida, T. Taniguchi, M. Sasaki, Y. Katsuya, K. Kitamura, H. Miyoshi: Structural studies on translation initiation factor 4E. Acta Crystallographica Section A Foundations of Crystallography 08/2002; 58(s1)., DOI:10.1107/S0108767302096113
  • A Asano, K Minoura, T Yamada, A Numata, T Ishida, Y Katsuya, Y Mezaki, M Sasaki, T Taniguchi, M Nakai, H Hasegawa, A Terashima, M Doi: Effect of asymmetric modification on the conformation of ascidiacyclamide analogs. European Journal of Allergy and Clinical Immunology 08/2002; 60(1):10-22., DOI:10.1034/j.1399-3011.2002.02981.x
  • Katsuhiko Minoura, Koji Tomoo, Toshimasa Ishida, Hiroshi Hasegawa, Masahiro Sasaki, Taizo Taniguchi: Amphipathic helical behavior of the third repeat fragment in the tau microtubule-binding domain, studied by H-1 NMR spectroscopy. Biochemical and Biophysical Research Communications 07/2002; 294(2):210-4., DOI:10.1016/S0006-291X(02)00457-6
  • Koji Tomoo, Xu Shen, Koumei Okabe, Yoshiaki Nozoe, Shoichi Fukuhara, Shigenobu Morino, Toshimasa Ishida, Taizo Taniguchi, Hiroshi Hasegawa, Akira Terashima, Masahiro Sasaki, Yoshio Katsuya, Kunihiro Kitamura, Hiroshi Miyoshi, Masahide Ishikawa, Kin-ichiro Miura: Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. Biochemical Journal 04/2002; 362(Pt 3):539-44.
  • Satoshi Tanimukai, Hiroshi Hasegawa, Masamichi Nakai, Keiko Yagi, Midori Hirai, Naoaki Saito, Taizo Taniguchi, Akira Terashima, Minoru Yasuda, Toshio Kawamata, Chikako Tanaka: Nanomolar amyloid β protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells. Neuroreport 04/2002; 13(4):549-53.
  • Satoshi Tanimukai, Hiroshi Hasegawa, Masamichi Nakai, Keiko Yagi, Midori Hirai, Naoaki Saito, Taizo Taniguchi, Akira Terashima, Minoru Yasuda, Toshio Kawamata, Chikako Tanaka: Nanomolar amyloid ?? protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells. Neuroreport 03/2002; 13(4):549-553., DOI:10.1097/00001756-200203250-00037
  • Koji TOMOO, Xu SHEN, Koumei OKABE, Yoshiaki NOZOE, Shoichi FUKUHARA, Shigenobu MORINO, Toshimasa ISHIDA, Taizo TANIGUCHI, Hiroshi HASEGAWA, Akira TERASHIMA, Masahiro SASAKI, Yoshio KATSUYA: Crystal structures of 7-methylguanosine 5′-triphosphate (m7GTP)- and P1-7-methylguanosine-P3-adenosine-5′, 5′-triphosphate (m7GpppA)-bound human full-length eukaryotic initiation factor 4E: Biological importance of the C-terminal flexible region. Biochemical Journal 03/2002; 362(3)., DOI:10.1042/0264-6021:3620539
  • Mitsunobu Doi, Saori Fujita, Yoshio Katsuya, Masahiro Sasaki, Taizo Taniguchi, Hiroshi Hasegawa: Antiparallel Pleated β-Sheets Observed in Crystal Structures of N,N-Bis(trichloroacetyl) and N,N-Bis(m-bromobenzoyl) Gramicidin S. Archives of Biochemistry and Biophysics 12/2001; 395(1):85-93., DOI:10.1006/abbi.2001.2567
  • Mitsunobu Doi, Toshimasa Ishida, Yoshio Katsuya, Masahiro Sasaki, Taizo Taniguchi, Hiroshi Hasegawa, Tsutomu Mimoto, Yoshiaki Kiso: KNI-272, a highly selective and potent peptidic HIV protease inhibitor. Acta Crystallographica Section C Crystal Structure Communications 12/2001; 57(Pt 11):1333-5., DOI:10.1107/S0108270101013701
  • Mitsunobu Doi, Akiko Asano, Yoshihide Usami, Yoshio Katsuya, Masamichi Nakai, Masahiro Sasaki, Taizo Taniguchi, Hiroshi Hasegawa: A folded conformation of an ascidiacyclamide derivative: 3-methoxysulfoxide-(2R,3R)-threoninyl desoxazoline-ascidiacyclamide. Acta Crystallographica Section E Structure Reports Online 11/2001; 57(11)., DOI:10.1107/S1600536801016129
  • Akiko Asano, Taizo Taniguchi, Masahiro Sasaki, Hiroshi Hasegawa, Yoshio Katsuya, Mitsunobu Doi: A β-sheet structure formed by C–H...O hydrogen bonds between the thiazole rings and amide bonds of a dimeric desoxazoline ascidiacyclamide analogue. Acta Crystallographica Section E Structure Reports Online 09/2001; 57(9)., DOI:10.1107/S160053680101279X
  • Hiroshi Hasegawa, Masamichi Nakai, Satoshi Tanimukai, Taizo Taniguchi, Akira Terashima, Toshio Kawamata, Kohji Fukunaga, Eishichi Miyamoto, Kazuyo Misaki, Hideyuki Mukai, Chikako Tanaka: Microglial signaling by amyloid β protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS. Neuroreport 09/2001; 12(11):2567-71., DOI:10.1097/00001756-200108080-00055
  • Masamichi Nakai, Satoshi Tanimukai, Keiko Yagi, Naoaki Saito, Taizo Taniguchi, Akira Terashima, Toshio Kawamata, Hideyuki Yamamoto, Kohji Fukunaga, Eishichi Miyamoto, Chikako Tanaka: Amyloid β protein activates PKC-δ and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia. Neurochemistry International 07/2001; 38(7):593-600., DOI:10.1016/S0197-0186(00)00126-1
  • A Oda, T Taniguchi, M Yokoyama: Leptin stimulates rat aortic smooth muscle cell proliferation and migration. The Kobe journal of medical sciences 07/2001; 47(3):141-50.
  • Mitsunobu Doi, Akiko Asano, Toshimasa Ishida, Yoshio Katsuya, Yoshihiro Mezaki, Masahiro Sasaki, Akira Terashima, Taizo Taniguchi, Hiroshi Hasegawa, Masaaki Shiono: Caged and clustered structures of endothelin inhibitor BQ123, cyclo(-D-Trp-D-Asp--Pro-D-Val-Leu-)·Na+, forming five and six coordination bonds between sodium ions and peptides. Acta Crystallographica Section D Biological Crystallography 06/2001; 57(Pt 5):628-34., DOI:10.1107/S0907444901002797
  • T Taniguchi, T Kawamata, H Mukai, H Hasegawa, T Isagawa, M Yasuda, T Hashimoto, A Terashima, M Nakai, H Mori, Y Ono, C Tanaka: Phosphorylation of Tau Is Regulated by PKN. Journal of Biological Chemistry 04/2001; 276(13):10025-31., DOI:10.1074/jbc.M007427200
  • Akiko Asano, Mitsunobu Doi, Kiyomi Kobayashi, Masao Arimoto, Toshimasa Ishida, Yoshio Katsuya, Yoshihiro Mezaki, Hiroshi Hasegawa, Masamichi Nakai, Masahiro Sasaki, Taizo Taniguchi, Akira Terashima: Effects of amino acids and chirality for molecular folding of desoxazoline-ascidiacyclamide derivatives: X-ray crystal structures of four cyclic octapeptides including unusual amino acids,cyclo(-Ile-aThr-D-Val-Thz-)2,cyclo(-Ala-aThr-D-Val-Thz-Ile-aThr-D-Val-Thz-),cyclo(-Val-aThr-D-Val-Thz-Ile-aThr-D-Val-Thz-), andcyclo(-Ile-aThr-Val-Thz-Ile-aThr-D-Val-Thz-). Biopolymers 03/2001; 58(3):295-304., DOI:10.1002/1097-0282(200103)58:3<295::AID-BIP1006>3.0.CO;2-X
  • Akiko Asano, Yoshio Katsuya, Masahiro Sasaki, Taizo Taniguchi, Hiroshi Hasegawa, Mitsunobu Doi: Crystal Structure of 2-[N-(t-Butoxycarbonyl)amino]-4-(thymin-1-yl)-butyric Acid Methyl Ester.. Analytical Sciences 03/2001; 17(2):361-2., DOI:10.2116/analsci.17.361
  • Mitsunobu Doi, Akiko Asano, Toshimasa Ishida, Yoshio Katsuya, Yoshihiro Mezaki, Masahiro Sasaki, Akira Terashima, Taizo Taniguchi, Hiroshi Hasegawa, Masaaki Shiono: Caged and clustered structures of endothelin inhibitor BQ123, cyclo(- D Trp D Asp − Pro D -Val-Leu-)\cdotNa + , forming five and six coordination bonds between sodium ions and peptides. DOI:10.1107/S0907444901002797/he0271sup1.cif
  • A Terashima, T Taniguchi, M Nakai, M Yasuda, T Kawamata, C Tanaka: Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca2+ signaling mechanism in rat hippocampal CA1 neurons. Neuropharmacology 08/2000; 39(10):1920-8., DOI:10.1016/S0028-3908(00)00015-0
  • Mitsunobu Doi, Toshimasa Ishida, Motomasa Kobayashi, Yoshio Katsuya, Yoshihiro Mezaki, Masahiro Sasaki, Akira Terashima, Taizo Taniguchi, Chikako Tanaka: Amphipathic structure of Theonellapeptolide-Id, a hydrophobic tridecapeptide lactone from the Okinawa marine spongeTheonella swinhoei. Biopolymers 07/2000; 54(1):27-34., DOI:10.1002/(SICI)1097-0282(200007)54:1<27::AID-BIP30>3.0.CO;2-3
  • Takayuki Isagawa, Hideyuki Mukai, Kumiko Oishi, Taizo Taniguchi, Hiroshi Hasegawa, Toshio Kawamata, Chikako Tanaka, Yoshitaka Ono: Dual Effects of PKNα and Protein Kinase C on Phosphorylation of Tau Protein by Glycogen Synthase Kinase-3β. Biochemical and Biophysical Research Communications 07/2000; 273(1):209-12., DOI:10.1006/bbrc.2000.2926
  • Mitsunobu Doi, Toshimasa Ishida, Yoshio Katsuya, Yoshihiro Mezaki, Masahiro Sasaki, Akira Terashima, Taizo Taniguchi, Hiroshi Hasegawa, Masaaki Shiono: Unique sodium-caged structure of a potent endothelin-1 inhibitor: Crystal structure of BQ123 sodium salt, cyclo(-D-Trp-D-Asp--Pro-D-Val-Leu- )·Na+. Chemical Communications 05/2000;, DOI:10.1039/a909413j
  • TOHRU Murayama, YOSHITAKE Hayashi, SHION Imoto, MANABU Shimoyama, HIROSHI Matsuoka, AKI Nagata, NOBUKO Iwata, TAIZO Taniguchi, MITSUHIRO Ito, HIROSHI Ito, KAZUO Chihara, TOSHIMITSU Matsui: Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome.. Hematology (Amsterdam, Netherlands) 02/2000; 5(2):163-165., DOI:10.1080/10245332.2000.11746503
  • M Nakai, K Hojo, K Yagi, N Saito, T Taniguchi, A Terashima, T Kawamata, T Hashimoto, K Maeda, M Gschwendt, H Yamamoto, E Miyamoto, C Tanaka: Amyloid beta protein (25-35) phosphorylates MARCKS through tyrosine kinase-activated protein kinase C signaling pathway in microglia. Journal of Neurochemistry 04/1999; 72(3):1179-86.
  • T. Kawamata, T. Taniguchi, H. Mukai, M. Kitagawa, T. Hashimoto, M. Nakai, A. Terashima, M. Yasuda, K. Maeda, Y. Ono, C. Tanaka: PKN phosphorylates tau protein and accumulates in Alzheimer neurofibrillary tangles. Neuroscience Research 12/1998; 31., DOI:10.1016/S0168-0102(98)82099-3
  • Akira Terashima, Taizo Taniguchi, Masamichi Nakai, Minoru Yasuda, Toshio Kawamata, Chikako Tanaka: Mechanism of induction of LTP by rapamycin in rat CA1 pyramidal neurons. Neuroscience Research 12/1998; 31., DOI:10.1016/S0168-0102(98)81991-3
  • Masamichi Nakai, Kaori Hojo, Taizo Taniguchi, Akira Terashima, Toshio Kawamata, Takeshi Hashimoto, Kiyoshi Maeda, Chikako Tanaka: PKC and tyrosine kinase involvement in amyloid β (25-35)-induced chemotaxis of microglia. Neuroreport 10/1998; 9(15):3467-3470., DOI:10.1097/00001756-199810260-00024
  • T Kawamata, T Taniguchi, H Mukai, M Kitagawa, T Hashimoto, K Maeda, Y Ono, C Tanaka: A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein. The Journal of Neuroscience 10/1998; 18(18):7402-10.
  • Takeshi Hashimoto, Hideyuki Mukai, Toshio Kawamata, Taizo Taniguchi, Yoshitaka Ono, Chikako Tanaka: Localization of PKN mRNA in the rat brain. Molecular Brain Research 09/1998; 59(2-59):143-153., DOI:10.1016/S0169-328X(98)00155-7
  • Akira Terashima, Masamichi Nakai, Takeshi Hashimoto, Toshio Kawamata, Taizo Taniguchi, Minoru Yasuda, Kiyoshi Maeda, Chikako Tanaka: Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. Brain Research 04/1998; 786(1-786):255-258., DOI:10.1016/S0006-8993(97)01435-2
  • T Hashimoto, T Kawamata, N Saito, M Sasaki, M Nakai, S Niu, T Taniguchi, A Terashima, M Yasuda, K Maeda, C Tanaka: Isoform-specific redistribution of calcineurin Aα and Aβ in the hippocampal CA1 region of gerbils after transient ischemia. Journal of Neurochemistry 04/1998; 70(3):1289-98.
  • Mitsunobu DOI, Toshimasa ISHIDA, Akira TERASHIMA, Taizo TANIGUCHI, Masahiro SASAKI, Chikako TANAKA: Polymorphism and C-H⋯O Interaction of Wortmannin, a Phosphatidylinositol 3-Kinase Inhibitor. Analytical Sciences 01/1998; 14(6):1191-1192., DOI:10.2116/analsci.14.1191
  • Akira Terashima, Takeshi Hashimoto, Taizo Taniguchi, Toshio Kawamata, Kiyoshi Maeda, Chikako Tanaka: Effects of immunosuppressants on postsynaptic membrane at induction of LTP. Neuroscience Research 12/1997; 28., DOI:10.1016/S0168-0102(97)81791-9
  • Oda, T. Taniguchi, A. Takahash, H. Shimizu, H. Yoshida, S. Kawasaki, Y. Okimura, K. Chihara, Y. Ishikawa, M. Yokoyama: 4.P.121 Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Atherosclerosis 10/1997; 134(1):321-321., DOI:10.1016/S0021-9150(97)89646-3
  • H. Yoshida, T. Taniguchi, A. Takahashi, H. Shimizu, A. Oda, S. Kawasaki, Y. Ishikawa, M. Yokoyama: 3.P.187 Cilostazol inhibits the rate of acetylated-LDL uptake by macrophages. Atherosclerosis 10/1997; 134(1):237-237., DOI:10.1016/S0021-9150(97)89260-X
  • Takahashi, T. Taniguchi, H. Shimizu, H. Yoshida, A. Oda, S. Kawasaki, Y. Ishikawa, M. Yokoyama: 3.P.260 Tranilast inhibits cyclin-dependent kinase-2 and cyclin-dependent kinase-4 activity by expression of p21 waf1/cip1. Atherosclerosis 10/1997; 134(1):253-253., DOI:10.1016/S0021-9150(97)89334-3
  • Taizo Taniguchi, Takeshi Hashimoto, Rika Taniguchi, Kenichi Shimada, Toshio Kawamata, Minoru Yasuda, Masamichi Nakai, Akira Terashima, Tamio Koizumi, Kiyoshi Maeda, Chikako Tanaka: Cloning of the cDNA encoding rat Presenilin-1. Gene 03/1997; 186(1):73-5., DOI:10.1016/S0378-1119(96)00683-X
  • T. Kawamata, T. Hashimoto, T. Taniguchi, S.Y. Niu, M. Nakai, M. Yasuda, A. Tcrashima, K. Macda, A. Nishimura, Y. Tatsuno, I. Akiguchi, P.L. McGeer, C. Tanaka: 547 Presenilin-1 (S182) immunobistochemistry in Alzheimer brain tissues. Neurobiology of Aging 12/1996; 17(4):S136., DOI:10.1016/S0197-4580(96)80549-5
  • T. Hashimoto, T. Kawamata, S.-Y. Niu, M. Sasaki, T. Taniguchi, A. Terashima, M. Nakai, M. Yasuda, K. Maeda, C. Tanaka: 737FK506 protects hippocampal CA1 neurons from transient cerebral ischemia. Neurobiology of Aging 12/1996; 17(4)., DOI:10.1016/S0197-4580(96)80739-1
  • T. Taniguchi, T. Hashimoto, R. Taniguchi, K. Shimada, T. Kawamata, M. Yasuda, M. Nakai, A. Terashima, T. Koizumi, K. Maeda, C. Tanaka: 57 Molecular cloning and characterization of rat S182 (presenilin-1) gene. Neurobiology of Aging 12/1996; 17(4)., DOI:10.1016/S0197-4580(96)80059-5
  • Taizo Taniguchi, Takeshi Hashimoto, Toshio Kawamata, Masamichi Nakai, Akira Terashima, Kiyoshi Maeda, Chikako Tanaka: 807 Cloning of rat S182 cDNA. Neuroscience Research 12/1996; 25., DOI:10.1016/0168-0102(96)88811-0
  • Takeshi Hashimoto, Toshio Kawamata, Masahiro Sasaki, Taizo Taniguchi, Akira Terashima, Masamichi Nakai, Kiyoshi Maeda, Chikako Tanaka: 1338 Protective effects of fk506 on apoptotic cell death in gerbil hippocampus after transient ischemia. Neuroscience Research 12/1996; 25., DOI:10.1016/0168-0102(96)88987-5
  • N Iwata, T Murayama, Y Matsumori, M Ito, A Nagata, T Taniguchi, K Chihara, Y Matsuo, J Minowada, T Matsui: Autocrine loop through cholecystokinin-B/gastrin receptors involved in growth of human leukemia cells. Blood 11/1996; 88(7):2683-9.
  • Tohru Murayama, Shion Imoto, Hiroshi Matsuoka, Nobuko Iwata, Taizo Taniguchi, Mitsuhiro Ito, Kazuo Chihara, Toshimitsu Matsui, Yoshitake Hayashi, Chiho Obayashi: Acute megakaryo‐monocytic leukemia with acute myelofibrosis. American Journal of Hematology 10/1996; 53(2):147-8., DOI:10.1002/(SICI)1096-8652(199610)53:2<147::AID-AJH20>3.0.CO;2-B
  • T Murayama, Y Matsumori, N Iwata, M Ito, T Taniguchi, K Chihara, T Matsui: Antiproliferative effect of a novel cholecystokinin-B/gaserin receptor antagonist, YM022. Cancer Science 08/1996; 87(7):743-50.
  • Tohru Murayama, Yoshinobu Matsumori, Nobuko Iwata, Mitsuhiro Ito, Taizo Taniguchi, Kazuo Chihara, Toshimitsu Matsui: Antiproliferative Effect of a Novel Cholecystokinin‐B/Gastrin Receptor Antagonist, YM022. Cancer Science 07/1996; 87(7):743 - 750., DOI:10.1111/j.1349-7006.1996.tb00287.x
  • Masamichi Nakai, Toshio Kawamata, Taizo Taniguchi, Kiyoshi Maeda, Chikako Tanaka: Expression of apoE mRNA in rat microglia. Neuroscience Letters 07/1996; 211(1-211):41-44., DOI:10.1016/0304-3940(96)12716-6
  • T Taniguchi, K Takaishi, T Murayama, M Ito, N Iwata, K Chihara, T Sasaki, Y Takai, T Matsui: Cholecystokinin-B/gastrin receptors mediate rapid formation of actin stress fibers. Oncogene 04/1996; 12(6):1357-60.
  • Yoshinobu Matsumori, Nobuyuki Katakami, Mitsuhiro Ito, Taizo Taniguchi, Nobuko Iwata, Tomoaki Takaishi, Kazuo Chihara, Toshimitsu Matsui: Cholecystokinin-B/Gastrin Receptor: A Novel Molecular Probe for Human Small Cell Lung Cancer. Cancer Research 02/1995; 55(2):276-9.
  • T MATSUI, T TANIGUCHI, T MURAYAMA, N IWATA, M ITO, K CHIHARA: BIOLOGICAL FUNCTION OF THE HUMAN CHOLECYSTOKININ-B GASTRIN RECEPTOR AND ITS SIGNALING PATHWAY INVOLVING TYROSINE KINASES. Journal of Cellular Biochemistry 01/1995;
  • M Ito, N Iwata, T Taniguchi, T Murayama, K Chihara, T Matsui: Functional Characterization of Two Cholecystokinin-B/ Gastrin Receptor lsoforms: A Preferential Splice Donor Site in the Human Receptor Gene. Molecular Cancer Research 11/1994; 5(10):1127-35.
  • T Murayama, T Matsui, Y Hayashi, T Taniguchi, M Ito, T Natazuka, S Imoto, N Iwata, T Isobe, H Ito: Plasma cell leukemia with myelofibrosis. Annals of Hematology 10/1994; 69(3):151-2., DOI:10.1007/BF01695697
  • T Takaishi, T Matsui, T Tsukamoto, M Ito, T Taniguchi, M Fukase, K Chihara: TGF-β-induced macrophage colony-stimulating factor gene expression in various mesenchymal cell lines. The American journal of physiology 08/1994; 267(1 Pt 1):C25-31.
  • T Taniguchi, T Matsui, M Ito, T Murayama, T Tsukamoto, Y Katakami, T Chiba, K Chihara: Cholecystokinin-B/gastrin receptor signaling pathway involves tyrosine phosphorylations of p125FAK and p42MAP. Oncogene 04/1994; 9(3):861-7.
  • Mitsuhiro Ito, Toshimitsu Matsui, Taizo Taniguchi, Kazuo Chihara: Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog. Gene 03/1994; 139(2):215-8., DOI:10.1016/0378-1119(94)90758-7
  • M Ito, T Matsui, T Taniguchi, T Tsukamoto, T Murayama, N Arima, H Nakata, T Chiba, K Chihara: Functional characterization of a human brain CCK-B receptor. Journal of Biological Chemistry 09/1993; 268(24):18300-5.
  • M ITO, T MATSUI, T TANIGUCHI, T TSUKAMOTO, T MURAYAMA, N ARIMA, H NAKATA, T CHIBA, K CHIHARA: Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin. Journal of Biological Chemistry 08/1993; 268(24):18300-18305.
  • Tomoyo Umemiya-Okada, Toshiki Natazuka, Toshimitsu Matsui, Mitsuhiro Ito, Taizo Taniguchi, Yoshinobu Nakao: Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines. Cancer Research 01/1993; 52(24):6961-5.
  • H Nakata, T Matsui, M Ito, T Taniguchi, Y Naribayashi, N Arima, A Nakamura, Y Kinoshita, K Chihara, S Hosoda: Cloning and characterization of gastrin receptor from ECL carcinoid tumor of Mastomys natalensis. Biochemical and Biophysical Research Communications 10/1992; 187(2):1151-7.
  • Hirohisa Nakata, Toshimitsu Matsui, Mitsuhiro Ito, Taizo Taniguchi, Yoko Naribayashi, Noriyuki Arima, Akira Nakamura, Yoshikazu Kinoshita, Kazuo Chihara, Shuyn Hosoda, Tsutomu Chiba: Cloning and characterization of gastrin receptor from ECL carcinoid tumor of. Biochemical and Biophysical Research Communications 09/1992; 187:1151-1157., DOI:10.1016/0006-291X(92)91317-J
  • T Taniguchi, T Matsuo, R Hishikawa, A Yamaguchi, S Akato, M Shibatouge: [Alpha 2plasmin-inhibitor . plasmin complex (PIC)--useful diagnostic and prognostic parameter]. Rinsho byori. The Japanese journal of clinical pathology 08/1991; 39(7):714-9.

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