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原著論文
Tabata H, Morita H, Kaji H, Tohyama K, Tohyama Y.* Syk facilitates phagosome-lysosome fusion by regulating actin-remodeling in complement- mediated phagocytosis. Sci Rep 10(1): 22086, 2020 (doi:10.1038/s41598-020-79156-7) Abstract
Morita H, Matsuoka A, Kida JI, Tabata H, Tohyama K, Tohyama Y. KIF20A, highly expressed in immature hematopoietic cells, supports the growth of HL60 cell line.
Int J Hematol. 108(6): 607-614, 2018(doi: 10.1007/s12185-018-2527-y.) Abstract
Kida JI, Tsujioka T, Suemori SI, Okamoto S, Sakakibara K, Takahata T, Yamauchi T, Kitanaka A, Tohyama Y, Tohyama K. An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS. Leukimia 32(8):1846-1850, 2018 (doi: 10.1038/s41375-018-0189-7. ) Abstract
Takechi-Haraya Y, Aki K, Tohyama Y, Harano Y, Kawakami T, Saito H, Okamura E. Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy. Pharmaceuticals (Basel) 10 (2): pii: E42 (doi: 10.3390/ph10020042.), 2017 Abstract
Okamoto S, Tsujioka T, Suemori SI, Kida JI, Kondo T, Tohyama Y, Tohyama K. Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression. Cancer Sci 107: 1302-1314,2016 Abstract
Tsujioka T, Yokoi A, Itano Y, Takahashi K, Ouchida M, Okamoto S, Kondo T, Suemori S, Tohyama Y, *Tohyama K: Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells. Sci Rep. 5:16709, doi:10.1038/srep16709, 2015. Abstract
Harahap NI, Nurputra DK, Rochmah MA, Shima A, Morisada N, Takarada T, Takeuchi A, Tohyama Y Yanagisawa S, Nishio H: Salbutamol inhibits ubiquitin-mediated survival motor neuron protein degradation in spinal muscular atrophy cells. Biochem Biophys Rep. 4: 351–356, doi:10.1016/j.bbrep.2015.10.012, 2015.
Kuroda Y, *Kato-Kogoe N, Tasaki E, Yuasa-Sunagawa M, Yamanegi K, Nakasyo K, Nakase I, Futaki S, Tohyama Y, Hirose M：Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells. Eur J Pharmacol.765: 24-33, 2015. Abstract
Yamamoto T, Sato H, Lai PS, Nurputra DK, Harahap NI, Morikawa S, Nishimura N, Kurashige T, Ohshita T, Nakajima H, Yamada H, Nishida Y, Toda S, Takanashi JI, Takeuchi A, Tohyama Y, Kubo Y, Saito K, Takeshima Y, Matsuo M, *Nishio H: Intragenic mutations in SMN1 may contribute more significantly to clinical severity than SMN2 copy numbers in some spinal muscular atrophy (SMA) patients. Brain Dev. 36(10): 914-20, 2014. Abstract
Kawakami T, He J, Morita H, Yokoyama K, Kaji H, Tanaka C, Suemori S, Tohyama K, Tohyama Y: Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells PLoS One 9(1):e84704. 2014 Abstract
Nurputra DK, Lai PS, Harahap NI, Morikawa S, Yamamoto T, Nishimura N, Kubo Y, Takeuchi A, Saito T, Takeshima Y, Tohyama Y, Tay SK, Low PS, Saito K, Nishio H: Spinal Muscular Atrophy: From Gene Discovery to Clinical Trials. Ann Hum Genet. 77(5):435-463. 2013 Abstract
Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F: Tubulin Polymerization Promoting Protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem. 288 (24):17313-35 2013 Abstract
Kuroda Y, Kato-Kogoe N, Tasaki E, Murata E, Ueda K, Abe M, Miyamoto K, Nakase I, Futaki S, Tohyama Y, Hirose M: Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells. Eur J Pharmacol. 698(1-3):87-94 2013 Abstract
Tsujioka T, Yokoi A, Kishimoto M, Kuyama A, Suemori S, Tohyama Y, Tohyama K: Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-deribed cell lines. Exp Hematol. 41(2):189-97 2013 Abstract
Tsujioka T, Matsuoka A, Tohyama Y, Tohyama K. Approach to New Therapeutics: Investigation by the Use of MDS-derived Cell Lines. Curr Pharm Des. 18(22):3204-14 2012 Review Abstract
Tanaka C, Kaji H, He J, Hazama R, Yokoyama K, Kinoshita E, Tsujioka T, Tohyama K, Yamamura H, Nishio H, Tohyama Y： Rab27b regulates c-kit expression by controling the secretion of stem cell factor. Biochem Biophys. Res Commun. 419(2): 368-73 (2012). Abstract
Yokoyama K, Kaji H, He J, Tanaka C, Hazama R, Kamigaki T, Ku Y, Tohyama K, Tohyama Y : Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes J Biol Chem. 286 (7):5375-82 (2011). Abstract
Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC： Protein kinase C delta-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases J Biol Chem. 285(53): 41896-910 (2010) Abstract
Matsuoka A, Tochigi A, Kishimoto M, Nakahara T, Kondo T, Tsujioka T, Tasaka T, Tohyama Y, Tohyama K: Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis. Leukemia. 4: 748-55 (2010) Abstract
Hazama R, Qu X, Yokoyama K, Tanaka C, Kinoshita E, He J, Takahashi S, Tohyama K, Yamamura H, Tohyama Y: ATP-induced osteoclast function; the formation of sealing-zone like structure and the secretion of lytic granules via microtubule-deacetylation under the control of Syk. Genes to Cells 14: 871-84. (2009) Abstract
Tohyama Y, Yamamura H: Protein-Tyrosine Kinase, Syk: A Key Player in Phagocytic Cells. J Biochem. 145(3): 267-73. (2009) Review Abstract
Kondo T, Okuno N, Naruse H, Kishimoto M, Tasaka T, Tsujioka T, Matsuoka A, Sugihara T, Tohyama Y, Tohyama K: Validation of the revised 2008 WHO diagnostic criteria in 75 suspected cases of myeloproliferative neoplasm. Leuk Lymphoma. 49(9): 1784-91. (2008) Abstract
Noda C, He J, Takano T, Tanaka C, Kondo T, Tohyama K, Yamamura H, Tohyama Y: Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells. Biochem Biophys Res Commun. 362:951-957. (2007) Abstract
Tohyama Y, Yamamura H. Complement-mediated phagocytosis - the role of Syk. IUBMB Life. 58(5): 304-308 (2006). Review Abstract
Shi Y, Tohyama Y, Kadono T, He J, Miah SMS, Hazama R, Tanaka C, Tohyama K, Yamamura H: Protein-tyrosine kinase, Syk is required for pathogen engulfment in complement-mediated phagocytosis. Blood. 107: 4554-4562, (2006) Abstract
Kurihara R, Tohyama Y, Matsusaka S, Kinoshita E, Naruse H, Tsujioka T, Katsumata Y, Yamamura H: Effects of peripheral cannabinoid receptor ligands on motility and polarization neutrophil-like HL60 cells and human neutrophils. J Biol Chem. 281: 12908-12918, (2006) “Paper of the Week” Abstract
Matsusaka, M., Tohyama, Y., He, J., Shi, Y., Hazama, R., Kadono, T., Kurihara, R., Tohyama, K., and Yamamura, H. Protein-tyrosine kinase, Syk is required for CXCL12-induced polarization of B cells. Biochem Biophys. Res Commun. 328(4): 1163-1169 (2005)
He, J., Tohyama, Y., Yamamoto, K., Kobayashi, M., Shi, Y., Takano, T., Noda, C., Tohyama, K., and Yamamura, H. Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function. Genes to Cells 10: 23-35 (2005)
Tohyama, Y., Takano,T., and Yamamura,H. B cell response to oxidative stress. Curr Pharm Des. 10(8):835-839 (2004) Review
Miah, S.M.S., Sada, K., Tuazon, P. T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J.A. and Yamamura, H. Activation of Syk protein-tyrosine kinase in response to osmotic stress requires the interaction with p21-activated protein kinase Pak2/-PAK. Mol Cell Biol. 24(1):71-83 (2004)
Nishihara T, Miura Y, Tohyama Y, Mizutani C, Hishita T, Ichiyama S, Uchiyama T, Tohyama K. Effects of the tyrosine kinase inhibitor imatinib mesylate on a Bcr-Abl-positive cell line: suppression of autonomous cell growth but no effect on decreased adhesive property and morphological changes. Int J Hematol. 78(3):233-40 (2003).
Tohyama, Y., Katagiri, K., Pardi, R., Lu, C., Springer, T-A. and Kinashi, T. The critical cytoplasmic regions of the lphaL/eta2 integrin in Rap1-induced adhesion and migration. Mol Biol Cell 14(6): 2570-2582 (2003)
Mizutani, C., Tohyama, Y., Miura, Y., Hishita, T., Nishihara, T., Yamamura, H., Ichiyama, S., Uchiyama, T. and Tohyama, K. Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation. Biochem Biophys. Res Commun. 297(3): 664-671 (2002)
Miura, H., Mizutani, C., Nishihara, T., Hishita, H., Yanagi, S., Tohyama, Y., Ichiyama, S., Yamamura, H., Uchiyama, T. and Tohyama, K. Adhesion via CD43 induces Syk activation and cell proliferation in TF-1 cells. Biochem Biophys. Res Commun. 288(1):80-86 (2001)
Hishita, T., Tada-Oikawa, S., Tohyama, K., Miura, Y., Nishihara, T., Tohyama, Y., Yoshida, Y., Uchiyama, T. and Kawanishi, S. Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Cancer Res. 61(7):2878-84 (2001)
Asahi, M., Azuma, T., Ito, S., Ito, Y., Suto, H., Nagai, Y., Tsubokawa, M., Tohyama, Y., Maeda, S., Omata, M., Suzuki, T. and Sasakawa, C. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med. 191(4):593-602 (2000)
Miura, Y., Tohyama, Y., Hishita, T., Lala A., De Nardin E., Yoshida, Y., Yamamura, H., Uchiyama, T. and Tohyama, K. Pyk2 and Syk participate in functional activation of granulocytic HL-60 cells in a different manner. Blood. 96(5):1733-1739 (2000)
Tohyama Y, Tohyama K, Tsubokawa M, Asahi M, Yoshida Y and Yamamura H. Outside-in signaling of soluble and solid-phase fibrinogen through integrin IIb3 is different and co-operative with each other in a megakaryoblastic leukemia cell line, CMK. Blood. 92(4):1277-1286, (1998).
Tsubokawa M, Tohyama Y, Tohyama K, Asahi M, Inazu T, Nakamura H, Saito H and Yamamura H. Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193. Eur J Biochem. 249(3):792-796, 1997.
Tohyama K, Tohyama Y, Nakayama T, Ueda T, Nakamura T and Yoshida Y. A novel factor-dependent human myelodysplastic cell line, MDS92, contains haemopoietic cells of several lineages. Br J Haematol. 91(4):795-799, 1995.
Tohyama Y, Yanagi S, Sada K and Yamamura H. Translocation of p72syk to the cytoskeleton in thrombin-stimulated platelets. J Biol Chem. 269(52):32796-32799, 1994.
Yanagi S, Sada K, Tohyama Y, Tsubokawa M, Nagai K, Yonezawa K and Yamamura H. Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation. Eur J Biochem. 224(2):329-333, 1994.
和文
通山由美 山村博平 Sykの発見から臨床応用まで 炎症と免疫 2012； 20（5月号）：272-277 特集II 低分子抗炎症薬の進歩 において
通山由美 補体依存性ファゴサイトーシスの分子機構-チロシンキナーゼSykの新たな機能 生化学 2006；78：878-882 みにれびゅう
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