専門分野

• 細胞生物学
• 神経科学

担当科目

• 機能形態学
• 生理学実習
• 基礎実験（生物）
• 模擬薬局実習
• 薬理系PBL
• 薬学応用演習
• 薬学総合演習
• 卒業研究

メッセージ

• 今日の自分は未来の自分に繋がっています。薬学部6年間を実りある日々にしていきましょう。

学歴

• 2000年 明治大学農学部農芸化学科 卒業

学位

• 博士（農学）

主な職歴

• 2025年- 姫路獨協大学薬学部 講師
• 2012-2022年 姫路獨協大学薬学部 助手

所属学会

• 日本薬学会

論文・解説

原著論文

• Hiromi Koma, Yasuhiro Yamamoto, Noboru Okamura, Tatsurou Yagami: A plausible involvement of plasmalemmal voltage-dependent anion channel 1 in the neurotoxicity of 15-deoxy-Δ^12,14-prostaglandin J₂. Brain and Behavior 10(12):e01866 (2020)
• Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami: The anti-neuron-specific enolase antibody induced neuronal cell death in a novel fashion. Molecular Neurobiology 57(5):2265-2278 (2020)
• Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami: 15-Deoxy-Δ ^12,14-prostaglandin J₂ Inhibits Cell Migration on Renal Cell Carcinoma via Down-Regulation of Focal Adhesion Kinase Signaling. Biol Pharm Bull 43(1):153-157 (2020)
• Hiromi Koma, Yasuhiro Yamamoto, Hiroaki Kumagai, Tatsurou Yagami: 4,4-Diisothiocyanatostilbene Disulfonic Acid Enhanced 15-Deoxy-Δ ^12,14-prostaglandin J₂-Induced Neuronal Apoptosis. Biol Pharm Bull 42(11):1913-1920 (2019)
• Hiromi Koma, Yasuhiro Yamamoto, Tomonari Fujita, Tatsurou Yagami: 15-deoxy-Δ^12,14-prostaglandin J₂ enhances anticancer activities independently of VHL status in renal cell carcinomas. Biochem Biophys Rep 18:100608 (2019)
• Yasuhiro Yamamoto, Hiromi Koma, Ayaka Nishii, Tatsurou Yagami: Anti-heat shock 70kDa protein antibody induced neuronal cell death. Biol Pharm Bull 40(4):402-412 (2018)
• Yasuhiro Yamamoto, Takehiro Yamamoto, Hiromi Koma, Ayaka Nishii, Tatsurou Yagami: Synergistic effects of 15-deoxy Δ^12,14-prostaglandin J₂ on the anti-tumor activity of doxorubicin in renal cell carcinoma. Biochem Biophys Rep 9:61-66 (2016)
• Hiromi Koma, Yasuhiro Yamamoto, Ayaka Nishii, Tatsurou Yagami: 15-deoxy-Δ^12,14-prostaglandin J₂ induced neurotoxicity via suppressing phosphoinositide 3-kinase. Neurophamacol 113:416-425 (2016)
• Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami: Localization of 14-3-3δ/ξ on the neuronal cell surface. Exp Cell Res 338:149-161 (2015)
• Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami: Hydrogen peroxide mediated the neurotoxicity of an antibody against plasmalemmal neuronspecific enolase in primary cortical neurons. Neurotoxicolgy 49:86-93 (2015)
• Yasuhiro Yamamoto, Hiromi Koma, Hiroki Hiramatsu, Misa Abe, Kazunori Murakami, Asako Ohya, Tatsurou Yagami: Hydrogen peroxide mediated the neurotoxicity of an antibody against plasmalemmal neuronspecific enolase in primary cortical neurons. Molecular and Clinical Oncology 2(2):292-296 (2014)
• Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Kohma: Leukotriene receptor antagonists, LY293111 and ONO-1078, protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors. Neurochem Int 63(3):163-171 (2013)
• Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Kohma, Tsutomu Nakamura, Nobuo Takasu, Noboru Okamura: L-type voltage-dependent calcium channel is involved in the snake venom group IA secretory phospholipase A2-induced neuronal apoptosis. Neurotoxicolgy 35:146-153 (2013)
• Yasuhiro Yamamoto, Megumi Fujita, Hiromi Koma, Motohiro Yamamori, Tsutomu Nakamura, Noboru Okamura, Tatsurou Yagami: 15-deoxy-Δ^12,14-prostaglandin J₂ enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. Biochem Biophys Res Commun 410(3):563-567 (2011)

総説・解説

• Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma: Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases. Mol Neurobiol 56(5):3090-3112 (2019)
• 矢上達郎・山本泰弘・高馬宏美: ユビキチン・プロテアソーム系における神経変性疾患メディエイター，シクロペンテノン型プロスタグランジンの作用. Medical Science Digest 45(4):81-84 (2019)
• Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma: Physiological and pathological roles of 15-deoxy-Δ^12,14-prostaglandin J₂ in the central nervous system and neurological diseases. Molecular Neurobiology 55(3):2227-2248 (2018)
• Tatsurou Yagami, Hiromi Koma, Yasuhiro Yamamoto: Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. Mol Neurobiol 53(7):4754-71 (2016)
• Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma: The role of secretory phospholipase A₂ in the central nervous system and neurological diseases. Mol Neurobiol 49(2):863-76 (2014)
• Tatsurou Yagami, Hiromi Kohma, Yasuhiro Yamamoto: L-type voltage-dependent calcium channels as therapeutic targets for neurodegenerative diseases. Current Medicinal Chemistry 19(28): 4816-4827 (2012)
• Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma, Kenkichi Takase: Arachidonate Cascade in the Intensive Insulin Therapy for Critically Ill Patients with Sepsis: Roles of Prostaglandins on Hyperglycemia-Impaired Immunity. Letters in Drug Design & Discovery 9 (6):557-567 (2012)

口頭発表・ポスター

• 高馬宏美、山本泰弘、矢上達郎：15-デオキシ-デルタ^12,14-プロスタグランジンJ₂の神経細胞毒性における電位依存性アニオンチャネル1の関与　日本薬学会第141年会　2021年3月
• 高馬宏美、山本泰弘、矢上達郎：腎癌細胞において15デオキシ-デルタ^12,14-プロスタグランジンJ₂はVHL非依存的に抗腫瘍効果を亢進する　日本薬学会第139年会（千葉）2019年3月
• Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami：A plausible involvement of plasmalemmal voltage-dependent anion channel in the neurotoxicity of 15-deoxy-Δ^12,14-prostaglandin J₂. 18th World Congress of Basic and Clinical Pharmacology 2018（京都）2018年7月
• 高馬宏美、山本泰弘、西井彩桂、矢上達郎：海馬において15-デオキシ-デルタ^12,14-プロスタグランジンJ₂はPI3キナーゼを抑制して記憶想起を低下させた　日本薬学会第137年会（仙台）2017年3月

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