“NMR of Drug Delivery Coupled with Lipid Membrane Dynamics” E.Okamura, in Encyclopedia of Biocolloid and Biointerface Science, Ed. by H. Ohshima, Volume 1, Chapter 30, pp. 391-402, John Wiley & Sons, Inc., 2016
『揺らぎ・ダイナミクスと生体機能—物理化学的視点から見た生体分子』(共著):化学同人(2013)
『製剤のための物理化学』(共著):廣川書店(2012)
『CBT対策と演習 物理化学』(共著):廣川書店(2009)
『薬学生のための生物物理化学入門』(共著):廣川書店(2008)
“NMR Studies on Lipid Bilayer Interfaces Coupled with Anesthetics and Endocrine Disruptors” E.Okamura and M.Nakahara, in Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications, Ed. by A.G. Volkov, Marcel Dekker, New York, pp.775-805 (2001).
論文・解説
原著論文
“Real-Time 1H NMR Reveals Position and Sequence Dependences of Amino Acid Isomerization in Amyloid Beta Fragments in Situ ” K. Aki, E. Okamura, Journal of Molecular Liquids, 364, 120050 (2022); https://doi.org/10.1016/j.molliq.2022.120050
“Real-time in-situ 1H NMR of reactions in peptide solution: preaggregation of amyloid-β fragments prior to fibril formation ” E. Okamura, K. Aki, Pure and Applied Chemistry , 92, 1575-1583 (2020); 10.1515/pac-2019-1201.
“Side-chain conformers to allow conversion from normal to isoaspartate in age-related proteins and peptides ” K. Aki, E. Okamura, BBA-Proteins and Proteomics, 1868, 140483 (2020). (https://doi.org/10.1016/j.bbapap.2020.140483).
“Isomerization of aspartyl residue in amyloid beta fragments: The kinetics by real-time 1H NMR under neutral and basic conditions” K. Aki, E. Okamura, J. Soln. Chem., 49(11), 1293-1303 (2020) (https://doi.org/10.1007/s10953-020-01018-7).
“Glycosaminoglycan Binding and Non-endocytic Membrane Translocation of Cell-permeable Octaarginine Monitored by Real Time In-cell NMR Spectroscopy” Y. Takechi-Haraya, K. Aki, Y. Tohyama, Y. Harano, T. Kawakami, H. Saito, and E. Okamura, Pharmaceuticals, 10, 42 (2017).
“Kinetics of the competitive reactions of isomerization and peptide bond cleavage at L-α- and D-β-aspartyl residues in an αA-crystallin fragment” K. Aki and E. Okamura, J. Pept. Sci., 23, 28-37 (2017).
“D-β-aspartyl residue exhibiting uncommon high resistance to spontaneous peptide bond cleavage” K. Aki and E. Okamura, Sci. Rep., 6, 21594 (2016).
“Staggered side-chain conformers of aspartyl residues prerequisite to transformation from L-α- to D-β- aspartate 58 in human-lens αA-crystallin fragment” K. Aki and E. Okamura, Biophys. Chem., 196, 10-15 (2015).
“Regulation of Phospholipid Protrusion in the Cell Sized Vesicle by Hydrophobic Bisphenol A” Y. Takechi, Y. Shintani, D. Kimoto, and E. Okamura, Membrane, 40, 38-45 (2015). 日本膜学会 「膜誌論文賞」受賞論文
“Uptake of Sevoflurane Limited by the Presence of Cholesterol in the Lipid Bilayer Membrane: A Multinuclear Nuclear Magnetic Resonance Study” E. Okamura, Y. Takechi, and K. Aki, J. Oleo Sci., 63, 1149-1157 (2014).
“Slow Tumbling but Large Protrusion of Phospholipids in the Cell Sized Giant Vesicle” Y. Takechi, H. Saito, and E. Okamura, Chem. Phys. Lett., 570, 136-140 (2013).
“Lateral Diffusion of Lipids Separated from Rotational and Translational Diffusion of a Fluid Large Unilamellar Vesicle” N. Yoshii, T. Emoto, and E. Okamura, Colloid Surf. B-Biointerfaces, 106, 22-27 (2013).
“Physicochemical Mechanism for the Lipid Membrane Binding of Polyarginine: the Favorable Enthalpy Change with Structural Transition from Random Coil to Alpha-Helix” Y. Takechi, C. Mizuguchi, M. Tanaka, T. Kawakami, S. Aimoto, E. Okamura, and H. Saito, Chem. Lett., 41, 1374-1376 (2012).
“Binding of Hydrophobic Fluorinated Bisphenol A to Large Unilamellar Vesicles of Egg Phosphatidylcholine” N. Yoshii, and E. Okamura, J. Phys. Chem. B, 115, 11074-11080 (2011).
“Kinetics of Binding and Diffusivity of Leucine-Enkephalin in Large Unilamellar Vesicle by Pulsed-Field-Gradient 1H NMR in Situ” N. Yoshii, T. Emoto, and E. Okamura, Biophysics, 7, 105-111 (2011).
“Kinetics of Membrane Binding and Dissociation of 5-Fluorouracil by Pulsed Field Gradient 19F NMR” N.Yoshii and E.Okamura, Chem. Phys. Lett., 474, 357-361 (2009).
“Drug Binding and Mobility Relating to the Thermal Fluctuation in Fluid Lipid Membranes” E.Okamura and N.Yoshii, J. Chem. Phys., 129, 215102 (2008).
“Cholesterol Location and Orientation in Aqueous Suspension of Large Unilamellar Vesicles of Phospholipid Revealed by Intermolecular Nuclear Overhauser Effect” C.Giordani, C.Wakai, K.Yoshida, E.Okamura, N.Matubayasi, and M.Nakahara, J. Phys. Chem. B, 112, 2622-2628 (2008).
“Dynamic and 2D NMR Studies on Hydrogen-bonding Aggregates of Cholesterol in Low-polarity Organic Solvents” C.Giordani, C.Wakai, E.Okamura, N.Matubayasi, and M.Nakahara, J. Phys. Chem. B, 110, 15205-15211 (2006).
“Mobility and Location of Anesthetics in Lipid Bilayer Membranes by High-Resolution, High-Field-Gradient NMR” E.Okamura and M.Nakahara, International Congress Series 1283, 203-206 (2005).
“Real-time In-cell 19F NMR Study on Uptake of Fluorescent and Nonfluorescent 19F-Octaarginines into Human Jurkat Cells” E.Okamura, K.Ninomiya, S.Futaki, Y.Nagai, T.Kimura, C.Wakai, N.Matubayasi, Y.Sugiura, and M.Nakahara, Chem. Lett. 34, 1064-1065 (2005).
“Limited Slowdown of Endocrine-Disruptor Diffusion in Confined Fluid Lipid Membranes” E.Okamura, C.Wakai, N.Matubayasi, Y.Sugiura, and M.Nakahara, Phys. Rev. Lett. 93, 248101 (2004), also selected for the Dec. 15, 2004 issue (Volume 8, Issue 12) of Virtual Journal of Biological Physics Research.
“NMR Study on the Binding of Neuropeptide Achatin-I to Phospholipid Bilayer: The Equilibrium, Location, and Peptide Conformation” T. Kimura, E.Okamura, N.Matubayasi, K. Asami, and M.Nakahara, Biophys. J., 87, 375-385 (2004).
“13C NMR Method for the Determination of Peptide and Protein Binding Sites in Lipid Bilayers and Emulsions” E.Okamura, T.Kimura, M.Nakahara, M.Tanaka, T.Handa, and H.Saito, J. Phys. Chem. B, 105, 12616-12621 (2001).
“Interactions of Phosphatidylcholine Surface Monolayers with Triglyceride Cores and Enhanced ApoA-I Binding in Lipid Emulsions” H.Saito, M.Tanaka, E.Okamura, T.Kimura, M.Nakahara, and T.Handa, Langmuir, 17, 2528-2532 (2001).
“NMR Specification of Lipid Bilayer Interfaces as Drug Delivery Sites” E.Okamura, R.Kakitsubo, and M.Nakahara, Stud. Surf. Sci. Catal., 132, 1045-1048 (2001).
“NMR Determination of the Delivery Site of Local Anesthetics in Phospholipid Bilayer Membranes” E.Okamura, R.Kakitsubo, and M.Nakahara, Prog. Anesth. Mech., 6 Special Issue, 542-547 (2000).
“NMR Study Directly Determining Drug Delivery Sites in Phospholipid Bilayer Membranes” E.Okamura and M.Nakahara, J. Phys. Chem. B, 103, 3505-3509 (1999).
“Molecular Dynamics Simulation of the Vibrational Spectra of Stearic Acid Monolayers at the Air/Water Interface” E.Okamura, N.Fukushima, and S.Hayashi, Langmuir, 15, 3589-3594 (1999).
“NMR Determination of the Delivery Site of Bisphenol A in Phospholipid Bilayer Membranes” E.Okamura, R.Kakitsubo, and M.Nakahara, Langmuir, 15, 8332-8335 (1999).
“14N NMR Spectra Sensitively Reflect Surface Curvature and Segmental Motion of Hydrophilic Headgroups in Lipid Bilayers and Micelles” E.Okamura, C.Wakai, N.Matubayasi, and M.Nakahara, Chem. Lett., 26, 1061-1062 (1997).
“Quantitative Analysis of Molecular Orientation in Chlorophyll a Langmuir Monolayer: A Polarized Visible Reflection Spectroscopic Study” E.Okamura, T.Hasegawa, and J.Umemura, Biophys. J., 69, 1142-1147 (1995).
“Monolayer Formation and Molecular Orientation of Various Helical Peptides at the Air/Water Interface” K.Fujita, S.Kimura, Y.Imanishi, E.Okamura, and J.Umemura, Langmuir, 11, 1675-1679 (1995).
“Orientation and Association of Helical Peptides in Phospholipid Bilayer Membrane” S.Kimura, J.Chou, Y.Imanishi, E.Okamura, and J.Umemura, in Peptide Chemistry, Ed. by M.Ohno, 1994, 133-136, Protein Research Foundation, Osaka (1995).
“Effects of Carnauba Wax Addition on Physical States of Palm Kernel Oil-in-Water Emulsions” Y.Matsumura, E.Okamura, H.Hidaka, M.Miyabe, and T.Mori, Biosci. Biotech. Biochem., 59, 1688-1693 (1995).
“Effect of Wax Addition on Gel – to – Liquid-Crystalline Phase Transition of Palm-Oil as Studied by FT-IR Spectroscopy” E.Okamura, Y.Matsumura, and T.Takenaka, Bull. Inst. Chem. Res., Kyoto Univ., 71, 188-192 (1993).
“Microstructure of Thin Langmuir-Blodgett Films of Dipalmitoylphosphatidylcholine – Electron Microscopic Images Replicated with Plasma Polymerized Film by Glow Discharge” E.Okamura, J.Umemura, K.Iriyama, and T.Araki, Chem. Phys. Lipids, 66, 219-223 (1993).
“Fourier Transform Infrared / Attenuated Total Reflection Study on Subtransition of Hydrated Dipalmitoylphosphatidylcholine Multibilayers” E.Okamura, J.Umemura, and T.Takenaka, Vibrational Spectrosc., 2, 95-100 (1991).
“A Comparative Study on Interactions of alpha-Aminoisobutyric Acid Containing Antibiotic Peptides, Trichopolyn I and Hypelcin A with Phosphatidylcholine Bilayers” K.Matsuzaki, T.Shioyama, E.Okamura, J.Umemura, T.Takenaka, Y.Takaishi, T.Fujita, and K.Miyajima, Biochim. Biophys. Acta, 1070, 419-428 (1991).
“Molecular Orientation in Thin Langmuir-Blodgett Films of Dipalmitoylphosphatidylcholine as Studied by FTIR Transmission and Reflection-Absorption Spectroscopy” E.Okamura, J.Umemura, and T.Takenaka, Can. J. Chem., 69, 1691-1694 (1991).
“High-Sensitivity Raman Spectroscopic Study on Surface-Pressure Dependence of the Structure in Thin Langmuir-Blodgett Films of Dipalmitoylphosphatidylcholine” E.Okamura, J.Umemura, and T.Takenaka, J. Raman Spectrosc., 22, 759-762 (1991).
“Orientation Studies of Hydrated Dipalmitoylphosphatidylcholine Multibilayers by Polarized FTIR-ATR Spectroscopy” E.Okamura, J.Umemura, and T.Takenaka, Biochim. Biophys. Acta, 1025, 94-98 (1990).
“Fourier Transform Infrared – Attenuated Total Reflection Spectroscopy of Hydration of Dimyristoylphosphatidylcholine Multibilayers” Lisbeth Ter-Minassian-Saraga, E.Okamura, J.Umemura, and T.Takenaka, Biochim. Biophys. Acta, 946, 417-423 (1988).
“Orientation of Gramicidin D Incorporated into Phospholipid Multibilayers: A Fourier Transform Infrared – Attenuated Total Reflection Spectroscopic Study” E.Okamura, J.Umemura, and T.Takenaka, Biochim. Biophys. Acta, 856, 68-75 (1986).
“Fourier Transform Infrared – Attenuated Total Reflection Spectra of Dipalmitoylphosphatidylcholine Monomolecular Films” E.Okamura, J.Umemura, and T.Takenaka, Biochim. Biophys. Acta, 812, 139-146 (1985).
“Calorimetric Studies of the Interaction between the Lecithin and Copolymers of L-Lysine and L-Leucine” M.Nakagaki and E.Okamura, Bull. Chem. Soc. Jpn., 58, 546-549 (1985).
“Penetration of Lysine-Leucine Copolymers into Lecithin Monolayers from Underlying Aqueous Solutions” M.Nakagaki, E.Okamura, and S.Kubota, Bull. Chem. Soc. Jpn., 56, 3730-3734 (1983).
“Penetration of Lysine Hydrochloride into Lecithin Monolayers from Underlying Aqueous Solutions” M.Nakagaki and E.Okamura, Bull. Chem. Soc. Jpn., 56, 1607-1611 (1983).
“Penetration of Leucine and Norleucine into Lecithin Monolayers from Underlying Aqueous Solutions” M.Nakagaki and E.Okamura, Bull. Chem. Soc. Jpn., 55, 3381-3385 (1982).
“The Penetration of Lysine into the Monolayers of Lecithin from the Underlying Aqueous Solutions” M.Nakagaki and E.Okamura, Bull. Chem. Soc. Jpn., 55, 1352-1356 (1982).
“臨床で役立つ麻酔作用機序:物理化学の目で見た麻酔薬のふるまい” 岡村恵美子, Life Support and Anesthesia, 28(6), 633-641 (2021).
“Solution NMR to Quantify Mobility in Membranes: Diffusion, Protrusion, and Drug Transport Processes” E. Okamura, Chem. Pharm. Bull., 67, 308-315 (2019).【Invited Review】
“化粧品開発が知って得する,コロイド分散系微粒子ベシクル・リポソームのメカニズム 第3回 ベシクル・リポソームの性質 Mechanism of Vesicles/Liposomes as Small Colloidal Particles for Cosmetics (3) Characterization of Vesicles and Liposomes” 岡村恵美子, COSMETIC STAGE, 11(3), 58-61 (2017).
“化粧品開発が知って得する,コロイド分散系微粒子ベシクル・リポソームのメカニズム 第2回 ベシクル・リポソームの測定法 Mechanism of Vesicles/Liposomes as Small Colloidal Particles for Cosmetics (2) Techniques for Characterization of Vesicle/Liposome” 岡村恵美子, COSMETIC STAGE, 11(2), 55-58 (2016).
“化粧品開発が知って得する,コロイド分散系微粒子ベシクル・リポソームのメカニズム 第1回 ベシクル・リポソームの種類と作り方 Mechanism of Vesicles/Liposomes as Small Colloidal Particles for Cosmetics (1) What is a Vesicle/Liposome: Its Classification and Method of Preparation” 岡村恵美子, COSMETIC STAGE, 11(1), 78-81 (2016).
“ Kinetics of Membrane Binding and Mobility of Drugs by Multinuclear Dynamic NMR in Situ ” E. Okamura, Journal of the Society of Japanese Women Scientists, 16, 7-14 (2016).
“Quantitative Analysis of Molecular Orientation in Ultra-thin Films by the External Reflection Spectrometry: a Fundamental Study for the Structural Analysis of Biomembrane” T.Hasegawa, E.Okamura, and J.Umemura, in Trends in Analytical Biosciences, Vol.1, No.18 (1997), electric publication at http://neo.pharm.hiroshima-u.ac.jp/ccab/.
口頭発表・ポスター
国際会議のみ
“Real-Time 19F NMR of Peptides in Solution: Preaggregation of Amyloid-β and α-synuclein, and cell entry of membrane-permeable peptides”, E. Okamura, The 37th International Conference on Solution Chemistry, July 25-28, 2022, Cartagena, Colombia (virtual) 【Invited】.
“Real-time peptide reactions by solution NMR: Preaggregation in amyloid-β fragment and cell entry of membrane-permeable peptide”, E. Okamura, PACIFICHEM 2021, December 16-21, 2021, Hawaii, USA (virtual) 【Invited】.
“Real-Time NMR Spectroscopy of Biologically Relevant Reaction: Preaggregation of Amyloid-β Fragments Prior to Fibril Formation”, E. Okamura, OKINAWA COLLOIDS 2019, November 3-8, 2019, Nago, Okinawa, Japan 【Invited】.
“Side-Chain Conformers of Aspartyl Residues to Allow Conversion from L-α- to D-β- or L-β-Aspartate in Age-Related Proteins and Peptides”, E. Okamura, K. Aki, The 4th International Conference on D-Amino Acid Research, September 10-13,2019, Tokyo, Japan.
“Kinetics of Peptide Bond Cleavage and Isomerization at Aspartyl Residue Using Real-time NMR Spectroscopy”, K. Aki, E. Okamura, The 4th International Conference on D-Amino Acid Research, September 10-13,2019, Tokyo, Japan.
“Real-Time in-Situ NMR of Biologically Relevant Reactions in Peptide Solution: Spontaneous Peptide Bond Cleavage of Aspartyl Isomers and Preaggregation of Amyloid-β Fragments”, E. Okamura, The 36th International Conference on Solution Chemistry, August 4-8, 2019, Xining, China 【Invited】.
“The Kinetics of Amino Acid Isomerization in Amyloid Beta Fragments Quantified by Real-Time 1H-NMR”, K. Aki, E. Okamura, The 36th International Conference on Solution Chemistry, August 4-8, 2019, Xining, China.
“How Sevoflurane Uptake is Regulated: The Effect of Membrane Curvature, Cholesterol, Lipid Composition, and Ion Channel”、Kotone Ito, Yukako Nishiguchi, Kenzo Aki, and Emiko Okamura、4th International Kyushu Colloid Colloquium, September 27-28, 2016, Hakata, Japan
“Real-Time in-Situ NMR Observation of Non-Enzymatic Peptide Bond Cleavage and Isomerization of Aspartyl Residue in Crystallin and Amyloid-β Fragments”、Kenzo Aki and Emiko Okamura、The XXVIIth International Conference on Magnetic Resonance in Biological Systems、August 21-26, 2016, Kyoto, Japan
“Mobility, location, and kinetics of membrane binding and delivery of drugs by solution-state 19F and 1H NMR”、Emiko Okamura、6th Asian Conference on Colloid and Interface Science、November 24-27, 2015, Sasebo, Nagasaki, Japan (Invited).
“Real Time in-Cell 19F NMR Spectroscopy on the Cell Membrane Permeation of Octaarginine”、Yuki Takechi, Kenzo Aki, Yumi Tohyama, Toru Kawakami, Hiroyuki Saito, and Emiko Okamura、The XXVIth International Conference on Magnetic Resonance in Biological Systems、August 24-29, 2014, Dallas, TX, USA
“Delivery of Sevoflurane Limited by the Presence of Cholesterol in Lipid Bilayer Membranes: Multinuclear, Dynamic NMR in Situ”、Emiko Okamura and Yuki Takechi、105th AOCS Annual Meeting & Expo、May 4-7, 2014, San Antonio, TX, USA
“Motions and Fluctuations of Phospholipid Molecules in Large and Cell Sized Vesicles by NMR ”、 Emiko Okamura, Yuki Takechi, Hiroyuki Saito, and Noriyuki Yoshii、33rd International Conference on Solution Chemistry、July 7-12, 2013、Kyoto, Japan
“Molecular Fluctuation of Lipids in Cell Sized Vesicles as Studied by NMR”、 Yuki Takechi, Hiroyuki Saito, and Emiko Okamura、The 6th International Symposium on Molecular Science of Fluctuations toward Biological Functions、December 5-6, 2012、Kyoto, Japan
“Static and Dynamic Behaviors of Drug Delivery to Lipid Bilayer Membrane by NMR and Molecular Dynamics Simulation”、Emiko Okamura and Noriyuki Yoshii、World Congress on Oleo Science & 29th ISF Congress、September 30-October 4, 2012、Nagasaki, Japan
“Kinetics of Membrane Binding and Mobility of Drugs by Multinuclear Dynamic NMR in Situ”、Noriyuki Yoshii, Tomomi Emoto, and Emiko Okamura、14th International Association of Colloid and Interface Scientists Conference、May 13-18, 2012、Sendai, Japan
“Physicochemical Mechanism for the Enhanced Ability of Lipid Membrane Penetration of Polyarginine”、Yuki Takechi, Haruka Yoshii, Masafumi Tanaka, Toru Kawakami, Saburo Aimoto, Emiko Okamura, and Hiroyuki Saito、14th International Association of Colloid and Interface Scientists Conference、May 13-18, 2012、Sendai, Japan
“Quantifying Rapid Association and Dissociation of Hydrophobic Fluorinated Bisphenol A to Lipid Bilayer”、 Noriyuki Yoshii, Tomomi Emoto, and Emiko Okamura、The 5th International Symposium on Molecular Science of Fluctuations toward Biological Functions、January 7-8, 2012、Nara, Japan
“Kinetics of Binding and Diffusivity of Leucine-enkephalin in Large Unilamellar Vesicle by Pulsed-field-gradient 1H NMR ”、 Noriyuki Yoshii, Tomomi Emoto, and Emiko Okamura、The 5th International Symposium on Molecular Science of Fluctuations toward Biological Functions、January 7-8, 2012、Nara, Japan
“Lateral Diffusion of Phospholipid Molecules Separated from the Rotational and the Translational Diffusion of a Fluid Bilayer Vesicle”、 Noriyuki Yoshii, and Emiko Okamura、The 4th International Symposium on Molecular Science of Fluctuations toward Biological Functions、November 30-December 1, 2010、Piaza Omi, Shiga, Japan
“Kinetics of Membrane Binding, Diffusivity, and Permeability of Small-Sized Drugs and Peptides by NMR in Situ”、E. Okamura and N. Yoshii、International Conference on Nanoscopic Colloid and Surface Science、September 19-22, 2010、Makuhari Messe, Chiba, Japan
“First Observation of Pure Lateral Diffusion of Lipid Molecules in a Bilayer Vesicle by Pulsed Field Gradient NMR Spectroscopy”、Emiko Okamura and Noriyuki Yoshii、The 3rd International Symposium on Molecular Science of Fluctuations toward Biological Functions、December 20-21, 2009、Toyoda Auditorium, Nagoya University, Nagoya, Japan
“Simulation of Pulsed Field Gradient NMR Spectra of Diffusive Motion of Lipids and Drugs Restricted by a Spherical Vesicle. A Monte Carlo study”、Noriyuki Yoshii and Emiko Okamura、 The 3rd International Symposium on Molecular Science of Fluctuations toward Biological Functions、December 20-21, 2009、Toyoda Auditorium, Nagoya University, Nagoya, Japan
“Drug Binding and Mobility Relating to the Thermal Fluctuation in Membranes: A Dynamic NMR Study”、Emiko Okamura and Noriyuki Yoshii、Joint International Open Symposium: Molecular Science of Fluctuations toward Biological Functions and Chemistry of Biological Processes Created by Water and Biomolecules、March 16-17, 2009、Okazaki Conference Center, Japan
“Pulsed-Field-Gradient NMR Method for Quantifying Drug Binding to Model Cell Membranes in Situ”、Emiko Okamura and Noriyuki Yoshii、The 82nd Colloid & Surface Science Symposium、June 15-18, 2008、NC State University, Raleigh, NC, USA
“Molecular Dynamics Study of Size- and Temperature-dependence of Thermodynamic Stability and Structure of SDS Micelle”、Noriyuki Yoshii, Emiko Okamura, and Susumu Okazaki、Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan、November 21-25, 2007、Fukuoka, Japan
“Mobility and Location of Anesthetics in Lipid Bilayer Membranes by High-Resolution, High-Field-Gradient NMR”、Emiko Okamura and Masaru Nakahara、The 7th International Conference on Basic and Systemic Mechanisms of Anesthesia、February 25-27, 2005、Nara, Japan
“Location and Side-Chain Conformation of a Neuropeptide, Achatin-I in Phospholipid Bilayer Membrane: A High-Resolution NMR Study”、Tomohiro Kimura, Emiko Okamura, Nobuyuki Matubayasi, and Masaru Nakahara、Biophysical Society 48th Annual Meeting、February 14-18, 2004、Baltimore, Maryland, USA
招待講演
“Real-Time 19F NMR of Peptides in Solution: Preaggregation of Amyloid-β and α-synuclein, and cell entry of membrane-permeable peptides”, E. Okamura, The 37th International Conference on Solution Chemistry, July 25-28, 2022, Cartagena, Colombia (virtual).
“Real-time peptide reactions by solution NMR: Preaggregation in amyloid-β fragment and cell entry of membrane-permeable peptide”, E. Okamura, 環太平洋国際化学会議(PACIFICHEM 2021), December 16-21, 2021, Hawaii, USA (virtual) .
“Real-Time NMR Spectroscopy of Biologically Relevant Reaction: Preaggregation of Amyloid-β Fragments Prior to Fibril Formation”, E. Okamura, OKINAWA COLLOIDS 2019, November 3-8, 2019, Nago, Okinawa, Japan.
“Real-Time in-Situ NMR of Biologically Relevant Reactions in Peptide Solution: Spontaneous Peptide Bond Cleavage of Aspartyl Isomers and Preaggregation of Amyloid-β Fragments”, E. Okamura, The 36th International Conference on Solution Chemistry, August 4-8, 2019, Xining, China.
Mobility, location, and kinetics of membrane binding and delivery of drugs by solution-state 19F and 1H NMR, 6th Asian Conference on Colloid and Interface Science, November 24-27, 2015, Sasebo, Nagasaki, Japan (Invited).
“Drug Binding and Mobility in Membranes by High-Resolution Solution NMR” The 47th Annual Meeting of the Biophysical Society of Japan, 2009年10月30日~11月1日 (Tokushima)
NMRによる膜中薬物の挙動の解析, 日本薬学会北陸支部特別講演会, 2009年6月25日 (富山)
“Drug Binding and Mobility in Model Cell Membranes in Situ: A Pulsed-Field-Gradient NMR Approach” Special Seminar, University of Pittsburgh, Molecular Biophysics and Structural Biology, 2008年6月19日 (Pittsburgh, USA)